Kanarek R B, Dushkin H
Department of Psychology, Tufts University, Medford, MA 02155.
Pharmacol Biochem Behav. 1988 Sep;31(1):113-22. doi: 10.1016/0091-3057(88)90321-8.
Recent research has led to the hypothesis that serotonergic mechanisms may be involved in both the control of energy intake and appetites for specific nutrients. Most of this research has focused on serotonin (5-HT) within the central nervous system. However, there is evidence which suggests that peripheral 5-HT also may be involved in the control of energy intake and nutrient selection. To further assess this suggestion, the effects of peripheral 5-HT administration on energy consumption and nutrient intakes were examined in adult male Sprague-Dawley rats given separate sources of protein, fat and carbohydrate. Administration of 5-HT (doses ranging from 2-6 mg/kg) led to significant dose-related decreases in total energy intake in both freely feeding and food-restricted rats. Examination of individual nutrient intakes revealed that following 5-HT, fat intake was more suppressed than either carbohydrate or protein intakes. Administration of the 5-HT antagonist, methysergide, blocked the suppressive effects of 5-HT on both total energy intake and fat intake. The present data support the proposal that peripheral serotonergic mechanisms play a role in ingestive behaviors.
近期的研究提出了一种假说，即血清素能机制可能参与能量摄入的控制以及对特定营养素的食欲调节。这项研究大多聚焦于中枢神经系统内的血清素（5-羟色胺，5-HT）。然而，有证据表明外周5-HT也可能参与能量摄入和营养素选择的控制。为了进一步评估这一观点，我们对成年雄性斯普拉格-道利大鼠进行了实验，这些大鼠被给予蛋白质、脂肪和碳水化合物的不同来源，研究外周给予5-HT对能量消耗和营养素摄入的影响。给予5-HT（剂量范围为2 - 6毫克/千克）导致自由进食和食物受限的大鼠的总能量摄入均出现显著的剂量相关下降。对个体营养素摄入的检查发现，给予5-HT后，脂肪摄入比碳水化合物或蛋白质摄入受到的抑制更明显。给予5-HT拮抗剂美西麦角可阻断5-HT对总能量摄入和脂肪摄入的抑制作用。目前的数据支持外周血清素能机制在摄食行为中起作用这一观点。
