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青霉素注射后发生的结核性骶髂关节炎:一例报告

Tuberculous Sacroiliitis after a Penicillin Injection: A Case Report.

作者信息

Darvishi Mohammad, Rashidi Sana, Abazari Setayesh

机构信息

Infectious Diseases and Tropical Medicine Research Center, Dept of Aerospace and Subaquatic Medicine, AJA University of Medical Sciences, Tehran, Iran.

Faculty of Medicine, Tehran Medical Branch, Islamic Azad University, Tehran, Iran.

出版信息

Eur J Case Rep Intern Med. 2020 Apr 9;7(6):001495. doi: 10.12890/2020_001495. eCollection 2020.

Abstract

UNLABELLED

Tuberculosis is one of the major health problems in developing countries affecting different organs such as bone and joints. One of the most important involvements of osteoarticular tuberculosis is that of the sacroiliac joint. In addition, its incidence has increased over the past several years. Early diagnosis is necessary to prevent further disorders such as neurological and surgical complications. We report a tuberculous arthritis case in the right sacroiliac joint, which developed after penicillin injection. The patient was a 32-year-old man admitted to Besat hospital, Tehran, Iran. He complained of pain, erythema and swelling in his right buttock starting approximately 17 years previously, after a penicillin injection, which was followed by the emergence of an orifice with yellow secretions. Over the years, the secretions continued but the pain, swelling and erythema were resolved. At the time of admission, his vital signs were stable and normal. In the physical examination, an orifice with a small amount of yellow secretion was detected on the right buttock as claimed by the patient. Lung auscultation was clear. No lymphadenopathy was detected. Laboratory data were normal. During hospitalization, initial antibiotic therapy was prescribed. After was detected in culture, a 4-drug anti-TB therapy encompassing rifampin, isoniazid, ethambutol and pyrazinamide was prescribed for 18-24 months, in addition to daily vitamin B6 and pantoprazole.

LEARNING POINTS

After confirmation of tuberculosis (TB), a 4-drug anti-TB therapy was administered for 18-24 months, together with daily vitamin B6 and pantoprazole.After 2 years of follow-up, MRI showed significantly reduced signal intensity of bone and soft tissue, but the size of the complex did not change in the sacroiliac joint.

摘要

未标注

结核病是发展中国家影响骨骼和关节等不同器官的主要健康问题之一。骨关节结核最重要的累及部位之一是骶髂关节。此外,其发病率在过去几年有所上升。早期诊断对于预防诸如神经和手术并发症等进一步的病症是必要的。我们报告一例右侧骶髂关节结核性关节炎病例,该病例在青霉素注射后发生。患者是一名32岁男性,入住伊朗德黑兰的贝萨特医院。他诉说大约17年前在一次青霉素注射后,右侧臀部开始出现疼痛、红斑和肿胀,随后出现一个有黄色分泌物的小孔。多年来,分泌物持续存在,但疼痛、肿胀和红斑消退。入院时,他的生命体征稳定且正常。体格检查时,如患者所述,在右侧臀部发现一个有少量黄色分泌物的小孔。肺部听诊清晰。未检测到淋巴结病。实验室数据正常。住院期间,开始使用初始抗生素治疗。培养物检测到(此处原文缺失相关内容)后,除每日给予维生素B6和泮托拉唑外,还开具了包含利福平、异烟肼、乙胺丁醇和吡嗪酰胺的四联抗结核治疗方案,疗程为18 - 24个月。

学习要点

确诊结核病后,给予四联抗结核治疗18 - 24个月,并每日补充维生素B6和泮托拉唑。经过2年的随访,MRI显示骨骼和软组织的信号强度显著降低,但骶髂关节处肿物的大小没有变化。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0aaf/7279915/21abc90be0b4/1495_Fig1.jpg

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