Iacobelli Silvia, Guignard Jean-Pierre
Néonatologie, Réanimation Néonatale et Pédiatrique, CHU La Réunion, Site Sud, Saint Pierre, France.
Centre d'Etudes Périnatales de l'Océan Indien, EA 7388, CHU La Réunion, Site Sud, Saint Pierre et Université de la Réunion, Réunion, France.
Pediatr Nephrol. 2021 Jun;36(6):1439-1446. doi: 10.1007/s00467-020-04632-1. Epub 2020 Jun 11.
Glomerular filtration rate (GFR) increases progressively throughout fetal life, matures rapidly after birth according to gestational and post-menstrual age, and reaches adult values by 1-year post-natal age. GFR is considered the best marker of kidney function, and in clinical practice, estimated GFR is useful to anticipate complications, establish prognosis, and facilitate treatment decisions. This review article summarizes the maturation of glomerular filtration and the factors and conditions that modulate and impair developing glomerular filtration, and discusses the techniques available to assess GFR in neonates and infants. We focused on simple, reliable, easily available, and cheap techniques to estimate GFR, which may provide valuable information on the renal aspects of the clinical care of this group of patients.
肾小球滤过率（GFR）在胎儿期会逐渐升高，出生后根据胎龄和月经龄迅速成熟，并在出生后1岁时达到成人水平。GFR被认为是肾功能的最佳指标，在临床实践中，估算的GFR有助于预测并发症、确定预后并辅助治疗决策。这篇综述文章总结了肾小球滤过的成熟过程以及调节和损害发育中肾小球滤过的因素与情况，并讨论了评估新生儿和婴儿GFR的可用技术。我们重点关注用于估算GFR的简单、可靠、易于获取且廉价的技术，这些技术可能为这组患者临床护理的肾脏方面提供有价值的信息。
