植物乳杆菌 TWK10 发酵豆浆可改善 2 型糖尿病大鼠的认知功能。
Lactobacillus plantarum TWK10-fermented soymilk improves cognitive function in type 2 diabetic rats.
机构信息
Department of Food Science, Fu Jen Catholic University, New Taipei City, Taiwan.
College of Human Ecology, Fu Jen Catholic University, New Taipei City, Taiwan.
出版信息
J Sci Food Agric. 2020 Nov;100(14):5152-5161. doi: 10.1002/jsfa.10564. Epub 2020 Jul 21.
BACKGROUND
The brain is especially sensitive to diabetes-induced damage. Chronic hyperglycemia can potentially lead to brain dysfunctions, affecting spatial learning and memory.
RESULTS
The type 2 diabetes (T2D) rats were administered TWK10-fermented soy milk water extract (WE) and ethanol extract (EE) for 6 weeks. WE and EE treatment attenuated T2D-induced alteration in cognitive function assessed using the Morris water maze. Moreover, administration of WE and EE significantly elevated superoxide dismutase activity (166.96% and 181.21%, P < 0.05, respectively) and reduced malondialdehyde concentration (35.03% and 43.97%, P < 0.05, respectively) in the hippocampus of the rats. Additionally, the calmodulin level and nitric oxide concentration were regulated by WE and EE.
CONCLUSION
This study provides scientific evidence that WE and EE enhance anti-oxidative enzyme activity, which subsequently regulates factors associated with cognitive function in T2D rats. © 2020 Society of Chemical Industry.
背景
大脑对糖尿病引起的损伤特别敏感。慢性高血糖可能导致大脑功能障碍，影响空间学习和记忆。
结果
2 型糖尿病（T2D）大鼠给予 TWK10 发酵豆浆水提取物（WE）和乙醇提取物（EE）治疗 6 周。WE 和 EE 治疗减轻了 TWK10 发酵豆浆水提取物和乙醇提取物治疗对使用 Morris 水迷宫评估的认知功能的改变。此外，WE 和 EE 给药显著提高了大鼠海马中超氧化物歧化酶的活性（分别为 166.96%和 181.21%，P<0.05），降低了丙二醛的浓度（分别为 35.03%和 43.97%，P<0.05）。此外，钙调蛋白水平和一氧化氮浓度受 WE 和 EE 调节。
结论
本研究提供了科学证据，表明 WE 和 EE 增强了抗氧化酶的活性，从而调节了 T2D 大鼠与认知功能相关的因素。 © 2020 化学工业协会。
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