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The human T-cell proliferative response to triple-knockout pig cells in mixed lymphocyte reaction.在混合淋巴细胞反应中人类T细胞对三基因敲除猪细胞的增殖反应。
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Enhanced suppression of the xenogeneic T-cell response in vitro by xenoantigen stimulated and expanded regulatory T cells.经异种抗原刺激和扩增的调节性 T 细胞可增强体外异种 T 细胞反应的抑制作用。
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Direct and indirect recognition of pig class II antigens by human T cells.人类T细胞对猪II类抗原的直接和间接识别。
Transplant Proc. 1995 Feb;27(1):258-9.
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Reduction of human-to-pig cellular response by alteration of porcine MHC with human HLA DPW0401 exogenes.通过用人HLA DPW0401外源性基因改变猪的主要组织相容性复合体来降低人对猪细胞的反应。
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The effective antigen presentation of human MHC on the lymphocytes of HLA DPW0401 transgenic pigs: examination with xenogenic mixed lymphocyte culture and primed lymphocyte tests.人MHC在HLA DPW0401转基因猪淋巴细胞上的有效抗原呈递：通过异种混合淋巴细胞培养和致敏淋巴细胞试验进行检测。
Transplant Proc. 2000 Nov;32(7):2503-4. doi: 10.1016/s0041-1345(00)01768-1.
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Xenogeneic thymokidney and thymic tissue transplantation in a pig-to-baboon model: I. Evidence for pig-specific T-cell unresponsiveness.猪到狒狒模型中的异种胸腺肾脏和胸腺组织移植：I. 猪特异性T细胞无反应性的证据
Transplantation. 2003 May 27;75(10):1615-24. doi: 10.1097/01.TP.0000064335.50622.20.
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Induction of human chimerism and functional suppressor cells in fetal pigs: feasibility of surrogate tolerogenesis for xenotransplantation.在胎猪中诱导人类嵌合体和功能性抑制细胞：异种移植替代耐受性诱导的可行性
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Induction of nonspecific, proliferative dependent suppressor T lymphocytes in human mixed lymphocyte cultures.人混合淋巴细胞培养中诱导非特异性、增殖依赖性抑制性T淋巴细胞
Cell Immunol. 1980 Nov;56(1):142-51. doi: 10.1016/0008-8749(80)90089-1.
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The autologous mixed lymphocyte reaction in cord blood lymphocytes: altered kinetics and magnitude of proliferative response compared to the adult autologous mixed lymphocyte reaction.脐血淋巴细胞中的自体混合淋巴细胞反应：与成人自体混合淋巴细胞反应相比，增殖反应的动力学和幅度发生改变。
J Clin Lab Immunol. 1985 Feb;16(2):87-90.
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Suppressive efficacy and proliferative capacity of human regulatory T cells in allogeneic and xenogeneic responses.人调节性T细胞在同种异体和异种反应中的抑制效力及增殖能力。
Transplantation. 2008 Nov 27;86(10):1452-62. doi: 10.1097/TP.0b013e318188acb0.

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2025: status of cardiac xenotransplantation including preclinical models.2025年：心脏异种移植的现状，包括临床前模型。
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In vitro and in vivo immune assessments of genetically-engineered pig skin grafts in New World (squirrel) monkeys.新型（松鼠）猴中基因工程猪皮移植物的体内外免疫评估。
Xenotransplantation. 2023 Nov-Dec;30(6):e12832. doi: 10.1111/xen.12832. Epub 2023 Oct 23.
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Xenotransplantation becoming reality.异种器官移植成为现实。
Transgenic Res. 2022 Jun;31(3):391-398. doi: 10.1007/s11248-022-00306-w. Epub 2022 May 11.
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HLA-G1 Expression in GGTA1KO Pigs Suppresses Human and Monkey Anti-Pig T, B and NK Cell Responses.GGTA1KO 猪中 HLA-G1 的表达抑制了人及猴抗猪 T、B 和 NK 细胞反应。
Front Immunol. 2021 Sep 9;12:730545. doi: 10.3389/fimmu.2021.730545. eCollection 2021.

本文引用的文献

1
Long-term survival of pig-to-rhesus macaque renal xenografts is dependent on CD4 T cell depletion.猪到恒河猴肾脏异种移植物的长期存活依赖于 CD4 T 细胞耗竭。
Am J Transplant. 2019 Aug;19(8):2174-2185. doi: 10.1111/ajt.15329. Epub 2019 Apr 5.
2
Carbohydrate antigen expression and anti-pig antibodies in New World capuchin monkeys: Relevance to studies of xenotransplantation.新世界卷尾猴的碳水化合物抗原表达和抗猪抗体：与异种移植研究的相关性。
Xenotransplantation. 2019 May;26(3):e12498. doi: 10.1111/xen.12498. Epub 2019 Feb 16.
3
Glycans as Key Checkpoints of T Cell Activity and Function.糖链作为 T 细胞活性和功能的关键检查点。
Front Immunol. 2018 Nov 27;9:2754. doi: 10.3389/fimmu.2018.02754. eCollection 2018.
4
Modified glycan models of pig-to-human xenotransplantation do not enhance the human-anti-pig T cell response.猪到人的异种移植的改良聚糖模型不会增强人抗猪T细胞反应。
Transpl Immunol. 2016 Mar;35:47-51. doi: 10.1016/j.trim.2016.02.001. Epub 2016 Feb 9.
5
The fate of human platelets exposed to porcine renal endothelium: a single-pass model of platelet uptake in domestic and genetically modified porcine organs.暴露于猪肾内皮的人血小板的命运：家猪和转基因猪器官中血小板摄取的单程模型。
J Surg Res. 2016 Feb;200(2):698-706. doi: 10.1016/j.jss.2015.08.034. Epub 2015 Aug 28.
6
Preventing T cell rejection of pig xenografts.预防 T 细胞对猪异种移植物的排斥。
Int J Surg. 2015 Nov;23(Pt B):285-290. doi: 10.1016/j.ijsu.2015.07.722. Epub 2015 Aug 22.
7
Enhanced T cell function in a mouse model of human glycosylation.增强人糖基化小鼠模型中的 T 细胞功能。
J Immunol. 2013 Jul 1;191(1):228-37. doi: 10.4049/jimmunol.1202905. Epub 2013 May 24.
8
The effect of Gal expression on pig cells on the human T-cell xenoresponse.Gal 表达对猪细胞人 T 细胞异种反应的影响。
Xenotransplantation. 2012 Jan-Feb;19(1):56-63. doi: 10.1111/j.1399-3089.2011.00691.x.
9
Suppressive efficacy and proliferative capacity of human regulatory T cells in allogeneic and xenogeneic responses.人调节性T细胞在同种异体和异种反应中的抑制效力及增殖能力。
Transplantation. 2008 Nov 27;86(10):1452-62. doi: 10.1097/TP.0b013e318188acb0.

The human T-cell proliferative response to triple-knockout pig cells in mixed lymphocyte reaction.

作者信息

Wang Zheng-Yu, Morsi Mahmoud, Nguyen Huy Quoc, Bikhet Mohamed, Burnette KaLia, Ayares David, Cooper David K C, Hara Hidetaka

机构信息

Xenotransplantation Program, Department of Surgery, University of Alabama at Birmingham, Birmingham, AL, USA.

Revivicor Inc., Blacksburg, VA, USA.

出版信息

Xenotransplantation. 2020 Sep;27(5):e12619. doi: 10.1111/xen.12619. Epub 2020 Jun 12.

DOI:10.1111/xen.12619
PMID:32529670
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7541622/
Abstract
摘要