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新型(再)用途的老药:嘌呤能调节可能扑灭 COVID-19 的血栓炎症风暴。

New (re)purpose for an old drug: purinergic modulation may extinguish the COVID-19 thromboinflammatory firestorm.

机构信息

Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.

Section of Vascular Thrombosis and Inflammation, National Heart, Lung, and Blood Institute, NIH, Bethesda, Maryland, USA.

出版信息

JCI Insight. 2020 Jul 23;5(14):140971. doi: 10.1172/jci.insight.140971.

Abstract

Purinergic signaling is discussed as a potential therapeutic target to reduced COVID-19 severity.

摘要

嘌呤能信号转导被认为是降低 COVID-19 严重程度的潜在治疗靶点。

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J Thromb Thrombolysis. 2021 Feb;51(2):446-453. doi: 10.1007/s11239-020-02324-z. Epub 2020 Nov 5.
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COVID-19-associated coagulopathy: An exploration of mechanisms.COVID-19 相关凝血功能障碍:机制探索。
Vasc Med. 2020 Oct;25(5):471-478. doi: 10.1177/1358863X20932640. Epub 2020 Jun 19.
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Neutrophil extracellular traps in COVID-19.中性粒细胞胞外陷阱在 COVID-19 中的作用。
JCI Insight. 2020 Jun 4;5(11):138999. doi: 10.1172/jci.insight.138999.
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Endothelial cell infection and endotheliitis in COVID-19.新型冠状病毒肺炎中的内皮细胞感染与内皮炎
Lancet. 2020 May 2;395(10234):1417-1418. doi: 10.1016/S0140-6736(20)30937-5. Epub 2020 Apr 21.

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