Schaefer Robert J, McCue Molly E
Department of Veterinary Population Medicine, College of Veterinary Medicine, University of Minnesota, 1365 Gortner Avenue, St Paul, MN 55108, USA.
Department of Veterinary Population Medicine, College of Veterinary Medicine, University of Minnesota, 1365 Gortner Avenue, St Paul, MN 55108, USA. Electronic address: https://twitter.com/Molly_McCue_DVM.
Vet Clin North Am Equine Pract. 2020 Aug;36(2):183-193. doi: 10.1016/j.cveq.2020.03.001. Epub 2020 Jun 10.
High-quality genomic tools have been integral in understanding genomic architecture and function in the modern-day horse. The equine genetics community has a long tradition of pooling resources to develop genomic tools. Since the equine genome was sequenced in 2006, several iterations of high throughput genotyping arrays have been developed and released, enabling rapid and cost-effective genotyping. This review highlights the design considerations of each iteration, focusing on data available during development and outlining considerations in selecting the genetic variants included on each array. Additionally, we outline recent applications of equine genotyping arrays as well as future prospects and applications.
高质量的基因组工具对于理解现代马的基因组结构和功能至关重要。马遗传学领域长期以来一直有集中资源开发基因组工具的传统。自2006年马基因组测序完成以来，已开发并发布了多个版本的高通量基因分型阵列，实现了快速且经济高效的基因分型。本综述重点介绍了每个版本的设计考量，着重于开发过程中可用的数据，并概述了在选择每个阵列上包含的遗传变异时的注意事项。此外，我们还概述了马基因分型阵列的近期应用以及未来前景和应用。
