Bai He, Yang Yunjiang, Bao Jinrong, Wu Anping, Qiao Yan, Guo Xueyuan, Wang Mingyuan, Li Wenxian, Liu Ying, Zhu Xiaowei
Inner Mongolia Key Laboratory of Chemistry and Physics of Rare Earth Materials, College of Chemistry and Chemical Engineering, Inner Mongolia Medical University, Hohhot 010110, People's Republic of China.
College of Pharmacology, Inner Mongolia Medical University, Hohhot 010110, People's Republic of China.
R Soc Open Sci. 2020 May 27;7(5):192235. doi: 10.1098/rsos.192235. eCollection 2020 May.
SiO@GdPO:Tb@SiO nanoparticles with core-shell-shell structure were successfully synthesized by a cheap silane coupling agent grafting method at room temperature. This method not only homogeneously coated rare-earth phosphate nanoparticles on the surface of silica spheres but also saved the use of rare-earth resources. The obtained nanoparticles consisted of SiO core with a diameter of approximately 210 nm, GdPO:Tb intermediate shell with thickness of approximately 7 nm, and SiO outer shell with thickness of approximately 20 nm. This unique core-shell-shell structured nanoparticles exhibited strong luminescence properties compared with GdPO:Tb nanoparticles. The core-shell-shell structured nanoparticles can effectively quench the intrinsic fluorescence of bovine serum albumin through a static quenching mode. The as-synthesized nanoparticles show great potential in biological cell imaging and cancer treatment.
通过廉价的硅烷偶联剂接枝法在室温下成功合成了具有核壳壳结构的SiO@GdPO₄:Tb@SiO纳米粒子。该方法不仅能将稀土磷酸盐纳米粒子均匀包覆在二氧化硅球表面，还节省了稀土资源的使用。所获得的纳米粒子由直径约210nm的SiO核、厚度约7nm的GdPO₄:Tb中间壳层和厚度约20nm的SiO外壳层组成。与GdPO₄:Tb纳米粒子相比，这种独特的核壳壳结构纳米粒子表现出较强的发光性能。核壳壳结构纳米粒子能够通过静态猝灭模式有效猝灭牛血清白蛋白的固有荧光。所合成的纳米粒子在生物细胞成像和癌症治疗方面显示出巨大潜力。
