Centre for Nanoscience and Technology, Pondicherry University, 605014, Puducherry, India.
Medical Imaging Research Centre, Dayananda Sagar Institutions, Bangalore, India.
J Biomed Mater Res B Appl Biomater. 2019 Jul;107(5):1372-1383. doi: 10.1002/jbm.b.34229. Epub 2018 Sep 28.
The proposed work involves an exclusive study on the synthesis protocol, crystal structure analysis, and imaging contrast features of unique lanthanide phosphates (LnPO ). XRD and Raman spectra affirmed the ability of the proposed synthesis technique to achieve unique LnPO devoid of impurities. The crystal structure analysis confirms the P121/c1 space setting of NdPO , EuPO , GdPO , and TbPO that all uniformly crystallizes in monoclinic unit cell. In a similar manner, the tetragonal crystal setting of DyPO , ErPO , HoPO , and YbPO that unvaryingly possess the I41/amd space setting is confirmed. Under the same synthesis conditions, the monoclinic (Eu) and tetragonal (Ho) lanthanide phosphates displayed uniform rod-like morphologies. Absorption and luminescence properties of unique LnPO were determined. In vitro biological studies demonstrated low toxicity levels of LnPO and clearly distinguished fluorescence of TbPO and EuPO in Y79, retinoblastoma cell lines. The paramagnetic response of GdPO , NdPO , DyPO , TbPO , and HoPO facilitated excellent magnetic resonance imaging (MRI) contrast features. Meanwhile, GdPO , DyPO , HoPO , and YbPO possessing higher X-ray absorption coefficient than clinical contrast Omnipaque™ exhibited high computed tomography (CT) efficiency. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B: 1372-1383, 2019.
本工作涉及独特的镧磷酸盐（LnPO）的合成方案、晶体结构分析和成像对比特性的专门研究。XRD 和拉曼光谱证实了所提出的合成技术能够实现无杂质的独特 LnPO。晶体结构分析证实了 NdPO、EuPO、GdPO 和 TbPO 采用 P121/c1 空间设置，它们均以单斜晶胞均匀结晶。同样，DyPO、ErPO、HoPO 和 YbPO 的四方晶系设置也得到了确认，它们都具有 I41/amd 空间设置。在相同的合成条件下，单斜（Eu）和四方（Ho）镧磷酸盐呈现出均匀的棒状形态。独特的 LnPO 的吸收和发光性能也得到了确定。体外生物学研究表明 LnPO 的毒性水平较低，并在 Y79、视网膜母细胞瘤细胞系中清楚地区分了 TbPO 和 EuPO 的荧光。GdPO、NdPO、DyPO、TbPO 和 HoPO 的顺磁响应促进了出色的磁共振成像（MRI）对比特性。同时，GdPO、DyPO、HoPO 和 YbPO 的 X 射线吸收系数高于临床对比剂 Omnipaque™，表现出高的计算机断层扫描（CT）效率。© 2018 年 Wiley 期刊，生物医学材料研究杂志 B 部分：应用生物材料 107B：1372-1383，2019 年。
