Institute of Psychiatry, Psychology & Neuroscience, Division of Neuroscience, King's College London, UK, www.radar-cns.org.
Epileptic Disord. 2020 Jun 1;22(3):245-251. doi: 10.1684/epd.2020.1158.
Despite representing the leading cause of epilepsy-related mortality, the pathophysiology of sudden unexpected death in epilepsy (SUDEP) remains elusive. In this context, the identification of clinical markers of SUDEP assumes a great importance and has been the target of many studies aimed at stratifying patients' individual risk. Among the potentially most hazardous post-ictal phenomena observed following convulsive seizures in monitored SUDEP cases, postictal generalized EEG suppression and postictal immobility have attracted attention as potential SUDEP risk factors. In this manuscript, we review the current knowledge on postictal generalized EEG suppression and postictal immobility, aiming to identify their pathophysiological mechanisms, reported frequencies and associated clinical factors, and critically evaluate the evidence on their potential relevance as SUDEP risk markers.
尽管癫痫相关性死亡的主要原因是癫痫猝死（SUDEP），但其病理生理学仍然难以捉摸。在这种情况下，识别 SUDEP 的临床标志物非常重要，这也是许多旨在对患者个体风险进行分层的研究的目标。在监测到的 SUDEP 病例中，癫痫发作后观察到的潜在最危险的癫痫后现象中，癫痫后广泛 EEG 抑制和癫痫后不动已引起关注，被认为是潜在的 SUDEP 危险因素。在本文中，我们回顾了癫痫后广泛 EEG 抑制和癫痫后不动的现有知识，旨在确定其病理生理学机制、报告的频率以及相关的临床因素，并批判性地评估它们作为 SUDEP 风险标志物的潜在相关性的证据。
