Rajakulendran Sanjeev, Nashef Lina
Department of Neurology, King's College Hospital, London, United Kingdom.
J Clin Neurophysiol. 2015 Feb;32(1):14-20. doi: 10.1097/WNP.0000000000000147.
Sudden unexpected death in epilepsy (SUDEP) remains a leading cause of epilepsy-related death, and yet, its pathogenic mechanisms remain ill-defined. Although epidemiological studies of SUDEP in heterogenous populations have established a number of clinical associations, evaluation and stratification of individual risk remains difficult. Thus, potential markers as predictors of risk of SUDEP are important not only clinically but also for research on SUDEP prevention. Recordings from rare monitored cases of SUDEP demonstrate postictal generalized EEG suppression after terminal seizures, raising expectations that postictal generalized EEG suppression may identify individuals at higher risk. In this review, we consider the literature on postictal generalized EEG suppression and evaluate its relevance and utility as a possible marker of SUDEP.
癫痫猝死（SUDEP）仍然是癫痫相关死亡的主要原因，然而，其致病机制仍不明确。尽管对异质人群中SUDEP的流行病学研究已经建立了一些临床关联，但对个体风险的评估和分层仍然困难。因此，作为SUDEP风险预测指标的潜在标志物不仅在临床上很重要，而且对于SUDEP预防研究也很重要。罕见的SUDEP监测病例记录显示，终末期癫痫发作后出现发作后广泛性脑电图抑制，这使得人们期望发作后广泛性脑电图抑制可能识别出高风险个体。在这篇综述中，我们考虑了关于发作后广泛性脑电图抑制的文献，并评估了其作为SUDEP可能标志物的相关性和实用性。
