Cummings S T, Fraser C G
Department of Biochemical Medicine, Ninewells Hospital and Medical School, Dundee, Scotland.
Ann Clin Biochem. 1988 Nov;25 ( Pt 6):634-7. doi: 10.1177/000456328802500606.
A series of ten 75 g oral glucose tolerance tests was carried out on each of 14 apparently healthy subjects. The analytical, intra-individual and interindividual components of variation were calculated by nested ANOVA following duplicate analyses of capillary plasma glucose under optimal conditions. The analyses met the objectively set analytical goal of CV less than or equal to 2.2%. There was considerable intra-individual variation, but no subject was ever classified as diabetic or having impaired glucose tolerance. Recent criteria for interpretation of results must be used since conventional population-based reference values are not adequate. Serial results from an individual must differ by more than 0.7 mmol/L for fasting specimens and at least 1.6 mmol/L for other specimens for a statistically significant (P less than or equal to 0.05) change to have occurred.
对14名表面健康的受试者每人进行了一系列10次75克口服葡萄糖耐量试验。在最佳条件下对毛细血管血浆葡萄糖进行重复分析后，通过嵌套方差分析计算变异的分析、个体内和个体间成分。这些分析达到了客观设定的CV小于或等于2.2%的分析目标。个体内存在相当大的变异，但没有受试者被归类为糖尿病患者或糖耐量受损。由于基于传统人群的参考值不适用，必须使用最新的结果解释标准。个体的系列结果，空腹样本的差异必须超过0.7 mmol/L，其他样本至少超过1.6 mmol/L，才会发生具有统计学意义（P小于或等于0.05）的变化。
