Ratzmann G W, Grimm U, Jährig K
Department of Paediatrics, Ernst-Moritz-Arndt University, Greifswald, G.D.R.
Biomed Biochim Acta. 1988;47(12):1037-41.
Plasma and cerebrospinal fluid concentrations of tyrosine and phenylalanine were measured fluorometrically in human term neonates appropriate for gestational age and in neonates small for gestational age with severe intra-uterine growth retardation of Type II. The intra-uterine retarded newborns showed significant differences of both plasma and cerebrospinal fluid tyrosine levels as compared with the non-retarded newborns: the mean plasma and cerebrospinal fluid tyrosine were determined to be 2.0 and 2.5 times, respectively, higher in the retarded group. The mean cerebrospinal fluid phenylalanine content was also increased in these newborns. The findings may reflect cellular disturbances of the tyrosine metabolization in the developing brain as it can also be found in experimental intra-uterine growth retarded animals.
采用荧光法测定了足月适于胎龄儿和患有II型严重宫内生长迟缓的小于胎龄儿的血浆及脑脊液中酪氨酸和苯丙氨酸的浓度。与未发生宫内生长迟缓的新生儿相比，宫内生长迟缓的新生儿血浆和脑脊液中的酪氨酸水平均存在显著差异：在生长迟缓组中，血浆和脑脊液酪氨酸的平均水平分别为对照组的2.0倍和2.5倍。这些新生儿脑脊液中的苯丙氨酸平均含量也有所增加。这些发现可能反映了发育中大脑酪氨酸代谢的细胞紊乱，这在实验性宫内生长迟缓动物中也有发现。
