National Demonstration Center for Experimental Fisheries Science Education, Shanghai Ocean University, Shanghai, China.
2The Key Laboratory of Exploration and Utilization of Aquatic Genetic Resources, Ministry of Education, Shanghai, China.
J Neuroendocrinol. 2020 Jun;32(6):e12876. doi: 10.1111/jne.12876. Epub 2020 Jun 15.
Ectotherm animals, such as fish, are vulnerable when facing an extreme temperature fluctuation as a result of their inability to maintain body temperature. The caudal neurosecretory system (CNSS) is unique to fish and has been shown to maintain homeostasis in response to seasonal changes. However, its temperature sensitivity is unknown. Here, we used in vitro electrophysiological and anatomical approaches to investigate a thermosensory pathway in the CNSS. We showed that the CNSS responds directly to local hypothermal challenge via the TRP channel, and transmits this signal using the neurotransmitter, GABA, to the neurosecretory Dahlgren cells of the CNSS. These findings are the first demonstration of the thermal perception of the CNSS and add to our understanding of the physiological role of the CNSS in thermoregulation and seasonal adaptation.
变温动物（如鱼类）由于无法维持体温，当面临极端温度波动时很脆弱。尾神经分泌系统（CNSS）是鱼类所特有的，已被证明可在季节性变化时维持体内平衡。然而，其对温度的敏感性尚不清楚。在这里，我们使用体外电生理学和解剖学方法来研究 CNSS 中的热敏途径。我们表明，CNSS 通过 TRP 通道直接对局部低温挑战做出反应，并使用神经递质 GABA 将此信号传递到 CNSS 的神经分泌 Dahlgren 细胞。这些发现首次证明了 CNSS 的热感知，并增加了我们对 CNSS 在体温调节和季节性适应中的生理作用的理解。
