Department of Internal Medicine, Sanggye Paik Hospital, Inje University College of Medicine, Seoul, South Korea.
Department of Internal Medicine, Hanyang University Hospital, Seoul, South Korea.
Aliment Pharmacol Ther. 2020 Jul;52(2):371-381. doi: 10.1111/apt.15867. Epub 2020 Jun 15.
It is controversial whether chronic hepatitis B (CHB) patients have more non-liver comorbidities than non-CHB subjects.
To characterise the demographics, comorbidity and health utilisation of CHB patients in South Korea and compare them to matched controls.
Using the Health Insurance Review & Assessment Service (HIRA) 2007-2016 database, adult patients with claims for CHB analysed. CHB cases and non-CHB controls matched in a 1:4 ratio using propensity score matching method.
The age of CHB patients significantly increased from a mean 46.9 years in 2007 to 52.3 years in 2016. The proportions of persons having both liver-related and non-liver related comorbidities were higher in CHB patients compared to matched controls (dyslipidaemia [37.23% vs 23.77%, P < 0.0001], hypertension [29.39% vs 25.27%, P < 0.0001] chronic kidney disease (CKD) [3.02% vs 1.14%, P < 0.0001] and osteoporosis/fracture [OF] [4.09% vs 3.23%, P < 0.0001]). Approximately 50% of CHB patients had more than one comorbidity among CKD, diabetes, DLP, and OF. The odds of CKD in CHB patients were 1.42 times higher, and the odds of OF in CHB patients were 1.09 times higher than matched controls after adjustment for confounders (P < 0.0001).
Prevalence of liver as well as non-liver comorbidities in patients with CHB was higher than matched controls and increased over time.
慢性乙型肝炎（CHB）患者是否比非 CHB 患者有更多的非肝脏合并症尚存争议。
描述韩国 CHB 患者的人口统计学、合并症和卫生利用情况，并将其与匹配对照进行比较。
使用健康保险审查与评估服务（HIRA）2007-2016 年数据库，对 CHB 患者进行分析。采用倾向评分匹配法，按 1:4 的比例对 CHB 病例和非 CHB 对照进行匹配。
CHB 患者的年龄从 2007 年的平均 46.9 岁显著增加到 2016 年的 52.3 岁。与匹配对照组相比，CHB 患者同时患有肝脏和非肝脏相关合并症的比例更高（血脂异常[37.23%比 23.77%，P<0.0001]、高血压[29.39%比 25.27%，P<0.0001]、慢性肾脏病（CKD）[3.02%比 1.14%，P<0.0001]和骨质疏松/骨折[OF] [4.09%比 3.23%，P<0.0001]）。约 50%的 CHB 患者同时患有 CKD、糖尿病、DLP 和 OF 中的一种以上合并症。在调整混杂因素后，CHB 患者发生 CKD 的可能性是匹配对照组的 1.42 倍，发生 OF 的可能性是匹配对照组的 1.09 倍（P<0.0001）。
与匹配对照组相比，CHB 患者肝脏和非肝脏合并症的患病率更高，且呈上升趋势。
