Department for Chemistry, University of Basel, Mattenstrasse 24a, 4002, Basel, Switzerland.
Chembiochem. 2020 Nov 2;21(21):3082-3086. doi: 10.1002/cbic.202000317. Epub 2020 Jul 14.
Cupin-type cysteine dioxygenases (CDOs) are non-heme iron enzymes that occur in animals, plants, bacteria and in filamentous fungi. In this report, we show that agaricomycetes contain an entirely unrelated type of CDO that emerged by convergent evolution from enzymes involved in the biosynthesis of ergothioneine. The activity of this CDO type is dependent on the ergothioneine precursor N-α-trimethylhistidine. The metabolic link between ergothioneine production and cysteine oxidation suggests that the two processes might be part of the same chemical response in fungi, for example against oxidative stress.
杯孢氨酸双加氧酶（CDO）是一类非血红素铁酶，存在于动物、植物、细菌和丝状真菌中。在本报告中，我们表明，伞菌纲真菌含有一种完全不同类型的 CDO，它是由参与麦角硫因生物合成的酶通过趋同进化而来的。这种 CDO 类型的活性依赖于麦角硫因前体 N-α-三甲基组氨酸。麦角硫因产生和半胱氨酸氧化之间的代谢联系表明，这两个过程可能是真菌中同一化学反应的一部分，例如对抗氧化应激。
