Department of Engineering, Klaipeda University , Klaipeda, Lithuania.
Mechanical Engineering Department, National Research Centre , Giza, Egypt.
Bioengineered. 2020 Dec;11(1):679-692. doi: 10.1080/21655979.2020.1775943.
Fracture in the hip joint is a major and quite common health issue, particularly for the elderly. The loads exploited by the lower limbs are very acute and severe; in the femur, they can be several folds higher than the whole weight of the body. Nanotechnology and nanocomposites offer great potential in biomedical applications. The organic materials are more biocompatible. Mechanical properties like strength and hardness are challenging parameters which control the selection of a joint. HDPE in its pure form has been successfully used as a prosthetic foot (external) but failed as an implant material due to limited mechanical properties. High-density polyethylene thermoplastic polymer (HDPE) and multi-walled carbon nanotubes (MWCNT)/Nano-Alumina is selected as a potential material for a biomedical implant and its mechanical properties and biocompatibility have been discussed. HDPE/MWCNT/Alumina (AlO) nanocomposites have not been explored yet for prosthetic implants. These nanocomposites were prepared in this investigation in different compositions. Prepared material has been physiochemically characterized to check the morphology and the structure. MWCNTs enhanced hardness and elastic modulus of the HDPE. Optimization of the material composition revealed that hybrid composite with structure (2.4% AlO and 0.6% MWCNT) exhibits better mechanical properties compared to other ratios with 3% MWCNTs and 5% MWCNTs. Thermal gravimetric analysis (TGA) dedicates that the percentage of crystallization has been increased to 6% after adding MWCNT to HDPE. The moisture absorption decreased to 90% with 5% MWCNT. Experimental results of Colorimetric assay (MTT) of a normal human epithelial cell line (1- BJ1) over AlO/MWCNT@HDPE showed <20% cytotoxic activity, proving its acceptance for medical use. HDPE/MWCNT/AlO nanocomposites emerged as a candidate material for artificial joints.
髋关节骨折是一个主要且相当常见的健康问题，特别是在老年人中。下肢承受的负荷非常剧烈和严重；在股骨中，它们可能是整个体重的数倍以上。纳米技术和纳米复合材料在生物医学应用中具有巨大的潜力。有机材料的生物相容性更好。强度和硬度等机械性能是控制关节选择的关键参数。纯高密度聚乙烯（HDPE）已成功用作假肢（外部），但由于机械性能有限，作为植入材料失败。高密度聚乙烯热塑性聚合物（HDPE）和多壁碳纳米管（MWCNT）/纳米氧化铝被选为生物医学植入物的潜在材料，其机械性能和生物相容性已进行了讨论。尚未探索 HDPE/MWCNT/Alumina（AlO）纳米复合材料用于假肢植入物。在这项研究中，以不同的成分制备了这些纳米复合材料。对制备的材料进行了物理化学特性分析，以检查其形态和结构。MWCNT 提高了 HDPE 的硬度和弹性模量。通过对材料成分的优化发现，具有结构（2.4%AlO 和 0.6%MWCNT）的混合复合材料比其他比例（3%MWCNT 和 5%MWCNT）具有更好的机械性能。热重分析（TGA）表明，在 HDPE 中添加 MWCNT 后，结晶度百分比增加到 6%。在添加 5%MWCNT 后，吸水率降低到 90%。在 AlO/MWCNT@HDPE 上对正常人类上皮细胞系（1-BJ1）进行比色法（MTT）实验的结果表明，<20%的细胞毒性活性，证明其可接受用于医疗用途。HDPE/MWCNT/AlO 纳米复合材料是人工关节的候选材料。
