Unit of Gastroenterology, Department of Medical Sciences, University of Turin, 10126 Turin, Italy.
Department of Medical Sciences, University of Turin, 10126 Turin, Italy.
Medicina (Kaunas). 2020 Jun 11;56(6):285. doi: 10.3390/medicina56060285.
Inflammatory bowel disease (IBD) is associated with an increased risk of developing colorectal cancer as well as some extra-intestinal tumors, but there are still limited data about the risk of prostate cancer (PC). To analyze if there is an increased risk of PC in patients affected by IBD, we performed a systematic review with meta-analysis. A Pubmed search of all studies comparing standardized incidence ratio (SIR) or odds ratio (OR) or relative risks (RR) of PC between IBD and non IBD groups, published until March 2020 was conducted. The study protocol was registered on PROSPERO. Twelve studies, mostly population studies, were included. The quality score of these studies, evaluated by the Newcastle-Ottawa Scale, was 7. The heterogeneity was high among the studies in which ulcerative colitis (UC) was considered separate from Crohn's disease (CD) and in the studies that considered UC and CD together ("IBD-studies"), while it was low in the studies which considered CD separate from UC. The relative risk of developing PC was 1.71 (95% confidence interval [CI] 1.16-2.51, = 0.007) in IBD, 1.10 (95%CI 0.98-1.25, = 0.116) in CD, and 1.22 (95%CI 0.98-1.51, = 0.07) in UC. Patients with IBD appear to have a slightly increased risk of PC compared to the general population.
炎症性肠病（IBD）与结直肠癌以及一些肠外肿瘤的发生风险增加有关，但关于前列腺癌（PC）的风险仍有限。为了分析 IBD 患者是否存在 PC 风险增加，我们进行了系统评价和荟萃分析。通过对截至 2020 年 3 月比较 IBD 组和非 IBD 组之间 PC 的标准化发病比（SIR）或比值比（OR）或相对风险（RR）的所有研究进行 Pubmed 检索，进行了系统评价和荟萃分析。研究方案已在 PROSPERO 上注册。共纳入 12 项研究，主要为人群研究。这些研究的质量评分（根据 Newcastle-Ottawa 量表评估）为 7 分。在将溃疡性结肠炎（UC）与克罗恩病（CD）分开考虑的研究中，以及同时考虑 UC 和 CD 的研究中（“IBD 研究”），研究之间存在高度异质性，但在将 CD 与 UC 分开考虑的研究中，异质性较低。IBD 患者发生 PC 的相对风险为 1.71（95%置信区间[CI] 1.16-2.51， = 0.007），CD 为 1.10（95%CI 0.98-1.25， = 0.116），UC 为 1.22（95%CI 0.98-1.51， = 0.07）。与一般人群相比，IBD 患者似乎 PC 风险略有增加。
