Department of Traditional Chinese Medicine, Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, N°321 Zhongshan Road, 210008 Nanjing, Jiangsu, China.
Department of Endocrinology, Kunshan Hospital on Integration of Chinese and Western Medicine, 215332 Jiangsu, China.
Clin Res Hepatol Gastroenterol. 2020 Jun;44(3):302-309. doi: 10.1016/j.clinre.2019.07.003. Epub 2019 Aug 23.
In recent years, some studies showed that inflammatory bowel disease (IBD) might be associated with an increased risk of prostate cancer (PC), whereas some other studies indicated that IBD was not associated with the increased risk of PC. In the present study, we aimed to conduct a systematic review and meta-analysis to evaluate the association of IBD and PC risk.
Web of Science and PubMed were systematically searched on for link of PC risk and IBD published from January 1976 to February 2019. The pooled multivariate odd ratio (OR) or relative risk (RR) and 95% confidence intervals (CI) were obtained by the use of STATA 12.0 software.
The meta-analysis indicated that IBD showed a 78% increase in PC risk (95% CI: 1.32-2.41). Sensitivity analyses showed no changes in the direction of effect after excluding any one study (supplementary figure 1). A significant heterogeneity was detected between different studies (Q test, P<0.001). Moreover, Begg's test, Egger's tests and funnel plots indicated no significant publication bias between included studies [Begg's test (P=0.371); Egger's test (p=0.100)].
The present meta-analysis demonstrated that IBD was associated with an increased diagnosis of PC. In addition, large scale prospective studies are essential to determine whether IBD increase the PC risk.
近年来，一些研究表明炎症性肠病（IBD）可能与前列腺癌（PC）风险增加有关，而另一些研究则表明 IBD 与 PC 风险增加无关。在本研究中，我们旨在进行系统评价和荟萃分析，以评估 IBD 和 PC 风险之间的关联。
系统检索了 Web of Science 和 PubMed 数据库，以获取自 1976 年 1 月至 2019 年 2 月发表的关于 PC 风险与 IBD 相关性的研究。使用 STATA 12.0 软件获得多变量优势比（OR）或相对风险（RR）和 95%置信区间（CI）。
荟萃分析表明，IBD 患者发生 PC 的风险增加了 78%（95%CI：1.32-2.41）。敏感性分析显示，排除任何一项研究后，效果方向没有变化（补充图 1）。不同研究之间存在显著的异质性（Q 检验，P<0.001）。此外，Begg 检验、Egger 检验和漏斗图表明纳入研究之间不存在显著的发表偏倚[Begg 检验（P=0.371）；Egger 检验（p=0.100）]。
本荟萃分析表明，IBD 与 PC 的诊断增加有关。此外，需要进行大规模前瞻性研究以确定 IBD 是否会增加 PC 风险。
