Łukasik Urszula, Kosior-Jarecka Ewa, Wróbel-Dudzińska Dominika, Kustra Agnieszka, Milanowski Piotr, Żarnowski Tomasz
Department of Diagnostics and Microsurgery of Glaucoma, Medical University of Lublin, Lublin, Poland.
Clin Ophthalmol. 2020 May 21;14:1373-1381. doi: 10.2147/OPTH.S239371. eCollection 2020.
The aim of this study was to describe clinical characteristics of glaucomatous optic neuropathy in treated Polish patients with pseudoexfoliative glaucoma.
In the course of the study, 348 eyes of 231 patients with pseudoexfoliative glaucoma. The patients involved in the study were treated in the Department of Diagnostic and Microsurgery of Glaucoma in Lublin between 2012 and 2019. The following parameters were assessed in the examination: visual acuity, slit-lamp biomicroscopy with evaluation of anterior segment of the eye, gonioscopic examination, stereoscopic fundus examination of the eye, intraocular pressure, visual field, and pachymetry.
The mean age of all the patients was 73.16 years (SD±8.03). The mean age of women was 74.06 (SD±6.97), and the mean age of men was 71.8 (SD±8.51, p=0.006265). Women represented 37.93% (n=132) of the studied group, while men 62.07% (n=216). In the group of patients younger than 65 years of age, 27.9% were male and 15% female (p=0.0021). In the whole studied group, mean peak IOP was 29.25 mmHg with higher mean values in male patients (M vs F: 33.24 mmHg vs 26.86 mmHg; p=0.000). Peak values exceeding 30 mmHg were significantly more frequent in males (M vs F: 56.5% vs 31.9%; p=0.0000). Peak IOP never exceeding 21 mmHg was observed in 18.6% of the patients. The mean value of MD (Mean Deviation) was -12.85 dB in the whole group. The men were more likely to have more advanced glaucoma, according to MD (M vs F: -16.35 dB vs -11.13 dB; p=0.0000).
Pseudoexfoliative glaucoma was more frequently observed in men with younger age, higher IOP, and more advanced glaucoma. Normotensive glaucoma was observed in 18.6% of the patients with pseudoexfoliative glaucoma.
本研究旨在描述接受治疗的波兰假性剥脱性青光眼患者青光眼性视神经病变的临床特征。
在研究过程中，纳入了231例假性剥脱性青光眼患者的348只眼。参与研究的患者于2012年至2019年在卢布林青光眼诊断与显微外科治疗。检查中评估了以下参数：视力、裂隙灯生物显微镜检查并评估眼前节、前房角镜检查、眼部立体眼底检查、眼压、视野和角膜测厚。
所有患者的平均年龄为73.16岁（标准差±8.03）。女性的平均年龄为74.06岁（标准差±6.97），男性的平均年龄为71.8岁（标准差±8.51，p = 0.006265）。女性占研究组的37.93%（n = 132），男性占62.07%（n = 216）。在年龄小于65岁的患者组中，男性占27.9%，女性占15%（p = 0.0021）。在整个研究组中，平均眼压峰值为29.25 mmHg，男性患者的平均值更高（男性与女性：33.24 mmHg对26.86 mmHg；p = 0.000）。眼压峰值超过30 mmHg的情况在男性中明显更常见（男性与女性：56.5%对31.9%；p = 0.0000）。18.6%的患者眼压峰值从未超过21 mmHg。整个组的平均MD（平均偏差）值为-12.85 dB。根据MD值，男性更易患更晚期的青光眼（男性与女性：-16.35 dB对-11.13 dB；p = 0.0000）。
假性剥脱性青光眼在年龄较轻、眼压较高且青光眼更晚期的男性中更常见。18.6%的假性剥脱性青光眼患者出现了正常眼压性青光眼。
