某大学医院原发性开角型青光眼和正常眼压性青光眼患者的特征：一项横断面回顾性研究。
Characteristics of patients with primary open angle glaucoma and normal tension glaucoma at a university hospital: a cross-sectional retrospective study.
作者信息
Yokoyama Yu, Maruyama Kazuichi, Konno Hideyuki, Hashimoto Sayaka, Takahashi Mai, Kayaba Hiroko, Kokubun Taiki, Nakazawa Toru
机构信息
Department of Ophthalmology, Tohoku University Graduate School of Medicine, 1-1, Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8574, Japan.
Department of Retinal Disease Control, Tohoku University Graduate School of Medicine, Miyagi, Japan.
出版信息
BMC Res Notes. 2015 Aug 19;8:360. doi: 10.1186/s13104-015-1339-x.
BACKGROUND
The characteristics of glaucoma patients and their response to therapy may differ by institution, region and country. Therefore, clinicians should understand the distinctiveness of their patients. Here, we profile primary open angle glaucoma (POAG) and normal tension glaucoma (NTG) patients at a major university hospital in Japan.
METHODS
This study included 523 eyes from 523 POAG and NTG patients who underwent full clinical ophthalmologic evaluations at Tohoku University Hospital. Clinical characteristics such as age, sex, visual acuity, intraocular pressure, Humphrey field analyzer-measured mean deviation (MD) and MD slope were collected retrospectively. MD slope was calculated from MD data that included the first baseline measurement of MD and 4 subsequent, consecutive, reliable measurements of MD. Refractive error was analyzed in a subgroup with no history of refractive surgery, including intraocular lens implantation. Patient characteristics were analyzed separately in the groups of patients with low (<15 mmHg) and high IOP (≥15 mmHg) and in the groups with MD slope ≥-1.0 and <-1.0 dB/year.
RESULTS
Mean age, visual acuity (median), IOP, pre-treatment IOP (from patient history), refractive error and MD were 61.7 ± 12.5 years, -0.08 (interquartile range -0.08 to 0.05) LogMAR, 13.87 ± 3.37 mmHg, 18.35 ± 6.26 mmHg, -4.48 ± 3.81 diopters and -11.73 ± 8.83 dB, respectively. POAG and NTG patients had significant differences in mean age (63.4 ± 12.4 vs. 60.7 ± 12.5 years, P < 0.01), visual acuity, IOP (14.95 ± 4.20 vs. 13.21 ± 2.54 mmHg, P < 0.01) and MD (-13.85 ± 9.32 vs. -10.45 ± 8.27 dB, P < 0.01). Interestingly, MD slope was slightly steeper in the low-IOP group than in the high-IOP group, although the difference was not statistically significant (-0.85 vs. -0.70 dB/year, P = 0.31). Baseline MD was significantly worse in the group with MD slope <-1.0 dB/year than in the group with MD slope ≥-1.0 dB/year (-11.56 vs. -7.64 dB/year, P < 0.01).
CONCLUSIONS
We identified characteristics of glaucoma patients at a university hospital that may reflect the specialized nature of such an institution.
背景
青光眼患者的特征及其对治疗的反应可能因机构、地区和国家而异。因此，临床医生应了解其患者的独特之处。在此，我们对日本一家大型大学医院的原发性开角型青光眼（POAG）和正常眼压性青光眼（NTG）患者进行了分析。
方法
本研究纳入了523例在东北大学医院接受全面临床眼科评估的POAG和NTG患者的523只眼睛。回顾性收集年龄、性别、视力、眼压、Humphrey视野分析仪测量的平均偏差（MD）和MD斜率等临床特征。MD斜率根据包含MD首次基线测量值以及随后4次连续可靠MD测量值的数据计算得出。对无屈光手术史（包括人工晶状体植入）的亚组患者的屈光不正进行了分析。分别在眼压低（<15 mmHg）和高（≥15 mmHg）的患者组以及MD斜率≥ -1.0和<-1.0 dB/年的患者组中分析患者特征。
结果
平均年龄、视力（中位数）、眼压、治疗前眼压（根据患者病史）、屈光不正和MD分别为61.7±12.5岁、-0.08（四分位间距-0.08至0.05）LogMAR、13.87±3.37 mmHg、18.35±6.26 mmHg、-4.48±3.81屈光度和-11.73±8.83 dB。POAG和NTG患者在平均年龄（63.4±12.4岁对60.7±12.5岁，P<0.01）、视力、眼压（14.95±4.20对13.21±2.54 mmHg，P<0.01）和MD（-13.85±9.32对-10.45±8.27 dB，P<0.01）方面存在显著差异。有趣的是，低眼压组的MD斜率比高眼压组略陡，尽管差异无统计学意义（-0.85对-0.70 dB/年，P = 0.31）。MD斜率<-1.0 dB/年的组的基线MD明显比MD斜率≥-1.0 dB/年的组差（-11.56对-7.64 dB/年，P<0.01）。
结论
我们确定了一家大学医院青光眼患者的特征，这些特征可能反映了该机构的专业性。
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