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子宫内膜癌预后性可变剪接特征的综合分析

Comprehensive Analysis of Prognostic Alternative Splicing Signatures in Endometrial Cancer.

作者信息

Chen Peigen, He Junxian, Ye Huixia, Jiang Senwei, Li Yunhui, Li Xiaomao, Wan Jing

机构信息

Department of Gynecology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.

出版信息

Front Genet. 2020 May 29;11:456. doi: 10.3389/fgene.2020.00456. eCollection 2020.

DOI:10.3389/fgene.2020.00456
PMID:32547595
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7272712/
Abstract

BACKGROUND

Alternative splicing (AS) is one of the critical post-transcriptional regulatory mechanisms of various cancers and also plays a crucial role in the development of cancers, including endometrial cancer (EC).

METHODS

The splicing data and gene expression profiles of EC were obtained from The Cancer Genome Atlas. The corresponding clinical data were extracted from TCGA-CDR. With univariate Cox regression analysis, least absolute shrinkage and selection operator model, and multivariate Cox regression analysis, the survival-related AS events were selected. Functional enrichment analysis was also performed to investigate the functions of these AS events. Splicing factors and AS regulation network were constructed to understand the correlation among these AS events.

RESULT

A total of 1826 AS events were identified as survival-related events. Functional enrichment analysis showed that these AS events were associated with several immune system-related processes. Then, the prognostic signatures were developed based on these survival-related events and acted as an independent prognostic factor for EC. Splicing factors and AS regulation network were also constructed to understand the regulatory mechanisms of AS events in EC.

CONCLUSION

This study systematically analyzed the role of AS events in EC and developed the prognostic model for EC.

摘要

背景

可变剪接（AS）是多种癌症关键的转录后调控机制之一，在包括子宫内膜癌（EC）在内的癌症发生发展中也起着至关重要的作用。

方法

从癌症基因组图谱获取EC的剪接数据和基因表达谱。从TCGA - CDR中提取相应的临床数据。通过单变量Cox回归分析、最小绝对收缩和选择算子模型以及多变量Cox回归分析，筛选出与生存相关的AS事件。还进行了功能富集分析以研究这些AS事件的功能。构建剪接因子和AS调控网络以了解这些AS事件之间的相关性。

结果

共鉴定出1826个与生存相关的AS事件。功能富集分析表明，这些AS事件与多个免疫系统相关过程有关。然后，基于这些与生存相关的事件建立了预后特征，并作为EC的独立预后因素。还构建了剪接因子和AS调控网络以了解AS事件在EC中的调控机制。

结论

本研究系统分析了AS事件在EC中的作用，并建立了EC的预后模型。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fae/7272712/253f8b5dc492/fgene-11-00456-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fae/7272712/d1d5111c9d59/fgene-11-00456-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fae/7272712/67e708496437/fgene-11-00456-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fae/7272712/bf10cf80c2a7/fgene-11-00456-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fae/7272712/3730c9ec77c2/fgene-11-00456-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fae/7272712/87b123c2c863/fgene-11-00456-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fae/7272712/253f8b5dc492/fgene-11-00456-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fae/7272712/d1d5111c9d59/fgene-11-00456-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fae/7272712/278cb9fd2f1d/fgene-11-00456-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fae/7272712/67e708496437/fgene-11-00456-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fae/7272712/bf10cf80c2a7/fgene-11-00456-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fae/7272712/3730c9ec77c2/fgene-11-00456-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fae/7272712/87b123c2c863/fgene-11-00456-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fae/7272712/253f8b5dc492/fgene-11-00456-g007.jpg

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2
Eleven genes associated with progression and prognosis of endometrial cancer (EC) identified by comprehensive bioinformatics analysis.通过全面的生物信息学分析鉴定出11个与子宫内膜癌（EC）进展和预后相关的基因。
Cancer Cell Int. 2019 May 20;19:136. doi: 10.1186/s12935-019-0859-1. eCollection 2019.
3
Identification of Potential Crucial Genes Associated With the Pathogenesis and Prognosis of Endometrial Cancer.
乳腺癌肿瘤中小非编码 RNA 的表达谱可表征临床病理特征，并具有预后和预测潜力。
Sci Rep. 2022 Dec 30;12(1):22614. doi: 10.1038/s41598-022-26954-w.
4
Comprehensive characterization of 11 prognostic alternative splicing events in ovarian cancer interacted with the immune microenvironment.全面分析卵巢癌中 11 个预后性可变剪接事件与免疫微环境的相互作用。
Sci Rep. 2022 Jan 19;12(1):980. doi: 10.1038/s41598-021-03836-1.
5
Identification of Tumor Microenvironment-Related Alternative Splicing Events to Predict the Prognosis of Endometrial Cancer.鉴定肿瘤微环境相关的可变剪接事件以预测子宫内膜癌的预后
Front Oncol. 2021 Apr 29;11:645912. doi: 10.3389/fonc.2021.645912. eCollection 2021.
6
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BMC Cancer. 2021 Mar 16;21(1):278. doi: 10.1186/s12885-021-08012-2.
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4
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5
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6
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Blood Cancer J. 2018 Aug 13;8(8):78. doi: 10.1038/s41408-018-0115-2.
8
An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics.TCGA 泛癌临床数据资源整合，推动高质量生存预后分析。
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9
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