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普拉德-威利综合征患者使用神经肌肉阻滞剂和舒更葡糖钠的麻醉管理:一例报告。

Anesthetic management with a neuromuscular relaxant and sugammadex in a patient with Prader-Willi syndrome: A case report.

作者信息

Kim Kyung Woo, Kim Seung Hwan, Ahn Eun Jin, Kim Hyo Jin, Choi Hey Ran, Bang Si Ra

机构信息

Department of Anesthesiology and Pain Medicine, Inje University Seoul Paik Hospital, Seoul, Korea.

出版信息

SAGE Open Med Case Rep. 2020 Jun 3;8:2050313X20927616. doi: 10.1177/2050313X20927616. eCollection 2020.

DOI:10.1177/2050313X20927616
PMID:32547762
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7273580/
Abstract

Prader-Willi syndrome is a genetic disorder that is characterized by obesity, characteristic facial features, hypotonia, and sleep apnea. These abnormalities mean that airway management is difficult in such patients. Several previous reports suggest that neuromuscular blocking agents should not be used to reduce airway and respiratory complications in these patients. However, this is not always possible. Here, we report the case of a patient with Prader-Willi syndrome in whom anesthesia for ophthalmic surgery was managed successfully using sugammadex after administration of rocuronium.

摘要

普拉德-威利综合征是一种遗传性疾病,其特征为肥胖、特殊面容、肌张力减退和睡眠呼吸暂停。这些异常情况意味着此类患者的气道管理具有挑战性。此前有几份报告表明,不应使用神经肌肉阻滞剂来减少这些患者的气道和呼吸并发症。然而,这并非总是可行的。在此,我们报告一例普拉德-威利综合征患者的病例,该患者在使用罗库溴铵后,通过舒更葡糖成功实施了眼科手术麻醉。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a595/7273580/c70e04ff8f5f/10.1177_2050313X20927616-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a595/7273580/c70e04ff8f5f/10.1177_2050313X20927616-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a595/7273580/c70e04ff8f5f/10.1177_2050313X20927616-fig1.jpg

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BMC Anesthesiol. 2025 Apr 17;25(1):188. doi: 10.1186/s12871-025-03013-1.

本文引用的文献

1
Anesthetic management in a pediatric patient with infantile phase Prader-Willi Syndrome: A case report.
Korean J Anesthesiol. 2009 Aug;57(2):259-263. doi: 10.4097/kjae.2009.57.2.259.
2
Optimal propofol induction dose in morbidly obese patients: A randomized controlled trial comparing the bispectral index and lean body weight scalar.病态肥胖患者丙泊酚诱导的最佳剂量:一项比较脑电双频指数和瘦体重标量的随机对照试验
Can J Anaesth. 2017 May;64(5):471-479. doi: 10.1007/s12630-017-0852-x. Epub 2017 Feb 27.
3
Local versus general anaesthesia for adults undergoing pars plana vitrectomy surgery.成人玻璃体切割手术中局部麻醉与全身麻醉的比较。
Cochrane Database Syst Rev. 2016 Sep 19;9(9):CD009936. doi: 10.1002/14651858.CD009936.pub2.
4
General anesthetic management of Prader-Willi syndrome patient undergoing middle cerebral artery-superficial temporal artery anastomosis.患有普拉德-威利综合征的患者行大脑中动脉-颞浅动脉吻合术时的全身麻醉管理
Korean J Anesthesiol. 2012 Jul;63(1):85-6. doi: 10.4097/kjae.2012.63.1.85. Epub 2012 Jul 24.
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Anesthesia for a 16-month-old patient with Prader-Willi syndrome.一名 16 个月大的 Prader-Willi 综合征患儿的麻醉。
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Sugammadex: another milestone in clinical neuromuscular pharmacology.舒更葡糖钠:临床神经肌肉药理学的又一个里程碑。
Anesth Analg. 2007 Mar;104(3):575-81. doi: 10.1213/01.ane.0000244594.63318.fc.
7
Anesthesia and Prader-Willi syndrome: preliminary experience with regional anesthesia.麻醉与普拉德-威利综合征:区域麻醉的初步经验
Paediatr Anaesth. 2006 Jul;16(7):712-22. doi: 10.1111/j.1460-9592.2006.01968.x.
8
Prader-Willi syndrome: causes of death in an international series of 27 cases.普拉德-威利综合征:27例国际病例系列的死亡原因
Am J Med Genet A. 2004 Feb 1;124A(4):333-8. doi: 10.1002/ajmg.a.20371.
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Anesthesia for pediatric patients with Prader-Willi syndrome: report of two cases.普拉德-威利综合征患儿的麻醉:两例报告
Chang Gung Med J. 2003 Jun;26(6):453-7.
10
Anaesthesia and Prader-Willi syndrome.麻醉与普拉德-威利综合征
Paediatr Anaesth. 1998;8(3):267-71. doi: 10.1046/j.1460-9592.1998.00689.x.