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人工胰腺成功治疗一名使用大剂量皮下注射胰岛素企图自杀的患者。

Successful treatment with artificial pancreas for a patient who attempted suicide using a high-dose insulin s.c. injection.

作者信息

Sakurai Toshihiro, Harada Masahiro, Takahashi Takeshi

机构信息

Department of Emergency and Critical Care Medicine National Hospital Organization Kumamoto Medical Center Kumamoto Japan.

出版信息

Acute Med Surg. 2020 Jun 12;7(1):e518. doi: 10.1002/ams2.518. eCollection 2020 Jan-Dec.

DOI:10.1002/ams2.518
PMID:32547770
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7292727/
Abstract

BACKGROUND

Artificial pancreas is usually used to manage hyperglycemia. We controlled prolonged hypoglycemia induced by insulin overdose using artificial pancreas.

CASE PRESENTATION

A 56-year-old female patient with type 2 diabetes mellitus was admitted to the emergency department after overdosing on 1,800 units each of insulin aspart and insulin degludec. She had also ingested 2 weeks of anti-anxiety medication. When the patient arrived at the hospital, her blood glucose level was 30 mg/dL and she was in a coma. Artificial pancreas (STG-55; Nikkiso, Tokyo, Japan) was used to control blood glucose levels because we were unable to predict the duration or degree of hypoglycemia. Blood glucose levels were safely controlled without the development of hypo- or hyperglycemia. Finally, the patient was discharged without any complications on day 7.

CONCLUSION

The STG-55 artificial pancreas was very useful and convenient for controlling blood glucose levels in our insulin overdose patient.

摘要

背景

人工胰腺通常用于管理高血糖。我们使用人工胰腺控制胰岛素过量引起的持续性低血糖。

病例介绍

一名56岁的2型糖尿病女性患者在过量注射1800单位门冬胰岛素和德谷胰岛素后被送往急诊科。她还服用了两周的抗焦虑药物。患者到达医院时,血糖水平为30mg/dL,处于昏迷状态。由于我们无法预测低血糖的持续时间或程度,因此使用人工胰腺(STG-55;日本东京日机装株式会社)来控制血糖水平。血糖水平得到安全控制,未出现低血糖或高血糖。最后,患者在第7天出院,无任何并发症。

结论

STG-55人工胰腺对于控制我们这位胰岛素过量患者的血糖水平非常有用且方便。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a138/7292727/4123b7d91430/AMS2-7-e518-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a138/7292727/4123b7d91430/AMS2-7-e518-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a138/7292727/4123b7d91430/AMS2-7-e518-g001.jpg

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Regarding a successful treatment with artificial pancreas for a patient who attempted suicide using a high-dose insulin s.c. injection.关于一名使用大剂量皮下注射胰岛素企图自杀的患者通过人工胰腺成功治疗的情况。
Acute Med Surg. 2020 Sep 20;7(1):e567. doi: 10.1002/ams2.567. eCollection 2020 Jan-Dec.

本文引用的文献

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Clin Pharmacokinet. 2014 Sep;53(9):787-800. doi: 10.1007/s40262-014-0165-y.
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Perioperative intensive insulin therapy using an artificial endocrine pancreas with closed-loop glycemic control system: the effects of no hypoglycemia.使用闭环血糖控制系统的人工内分泌胰腺进行围手术期强化胰岛素治疗:无低血糖的影响。
Am J Surg. 2014 Jun;207(6):935-41. doi: 10.1016/j.amjsurg.2013.07.048. Epub 2014 Jan 3.
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Blood glucose control using an artificial pancreas reduces the workload of ICU nurses.
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Pharmacokinetics and pharmacodynamics of insulin aspart, a rapid-acting analog of human insulin, in healthy Japanese volunteers.门冬胰岛素(一种人胰岛素速效类似物)在健康日本志愿者体内的药代动力学和药效学
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Receptor and postreceptor defects contribute to the insulin resistance in noninsulin-dependent diabetes mellitus.受体及受体后缺陷促成了非胰岛素依赖型糖尿病中的胰岛素抵抗。
J Clin Invest. 1981 Oct;68(4):957-69. doi: 10.1172/jci110350.
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Attempted suicide by insulin injection treated with artificial pancreas.采用人工胰腺治疗胰岛素注射所致自杀未遂。
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