Chen Long, Chen Yu, Feng Yuan-Ling, Zhu Yan, Wang Li-Quan, Hu Shen, Cheng Pu
Department of Radiotherapy, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou 310014, Zhejiang Province, China.
Department of Pediatric Surgery, Guangdong Women and Children Hospital, Guangzhou 511400, Guangdong Province, China.
World J Clin Cases. 2020 Jun 6;8(11):2066-2080. doi: 10.12998/wjcc.v8.i11.2066.
Digestive tract cancer is one of the main diseases that endanger human health. At present, the early diagnosis of digestive tract tumors mainly depends on serology, imaging, endoscopy, and so on. Although tissue specimens are the gold standard for cancer diagnosis, with the rapid development of precision medicine in cancer, the demand for dynamic monitoring of tumor molecular characteristics has increased. Liquid biopsy involves the collection of body fluids non-invasive approaches, and analyzes biological markers such as circulating tumor cells, circulating tumor DNA, circulating cell-free DNA, microRNAs, and exosomes. In recent years, liquid biopsy has become more and more important in the diagnosis and prognosis of cancer in clinical practice due to its convenience, non-invasiveness, high specificity and it overcomes temporal-spatial heterogeneity. Therefore, this review summarizes the current evidence on liquid biopsies in digestive tract cancers in relation to diagnosis and prognosis.
消化道癌是危害人类健康的主要疾病之一。目前，消化道肿瘤的早期诊断主要依靠血清学、影像学、内镜检查等。尽管组织标本是癌症诊断的金标准，但随着癌症精准医学的快速发展，对肿瘤分子特征动态监测的需求增加。液体活检涉及通过非侵入性方法采集体液，并分析循环肿瘤细胞、循环肿瘤DNA、循环游离DNA、微小RNA和外泌体等生物标志物。近年来，液体活检因其便捷、无创、高特异性且克服了时空异质性，在临床实践中对癌症的诊断和预后评估中变得越来越重要。因此，本综述总结了目前关于液体活检在消化道癌诊断和预后方面的证据。
