Hamideh Rezvani Alanagh, Akbari Babak, Fathi Parinaz, Misra Santosh K, Sutrisno Andre, Lam Fan, Pan Dipanjan
Department of Life Science Engineering, Faculty of New Sciences and Technologies, University of Tehran, P.O. Box 14395-1561, Tehran, Iran.
Department of Bioengineering, Beckman Institute of Advanced Science and Technology, Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Carle Foundation Hospital, 611 West Park Street, Urbana, IL, 61801, USA.
Adv Healthc Mater. 2020 Jul;9(14):e2000136. doi: 10.1002/adhm.202000136. Epub 2020 Jun 16.
Metal-organic frameworks (MOFs) have applications in numerous fields. However, the development of MOF-based "theranostic" macroscale devices is not achieved. Here, heparin-coated biocompatible MOF/poly(ε-caprolactone) (PCL) "theranostic" stents are developed, where NH -Materials of Institute Lavoisier (MIL)-101(Fe) encapsulates and releases rapamycin (an immunosuppressive drug). These stents also act as a remarkable source of contrast in ex vivo magnetic resonance imaging (MRI) compared to the invisible polymeric stent. The in vitro release patterns of heparin and rapamycin respectively can ensure a type of programmed model to prevent blood coagulation immediately after stent placement in the artery and stenosis over a longer term. Due to the presence of hydrolysable functionalities in MOFs, the stents are shown to be highly biodegradable in degradation tests under various conditions. Furthermore, there is no compromise of mechanical strength or flexibility with MOF compositing. The system described here promises many biomedical applications in macroscale theranostic devices. The use of MOF@PCL can render a medical device MRI-visible while simultaneously acting as a carrier for therapeutic agents.
金属有机框架材料（MOFs）在众多领域都有应用。然而，基于MOF的“治疗诊断一体化”宏观器件尚未得到发展。在此，开发了肝素包被的生物相容性MOF/聚己内酯（PCL）“治疗诊断一体化”支架，其中拉瓦锡研究所材料（MIL）-101（Fe）包封并释放雷帕霉素（一种免疫抑制药物）。与不可见的聚合物支架相比，这些支架在体外磁共振成像（MRI）中也是显著的对比源。肝素和雷帕霉素的体外释放模式分别可以确保一种程序化模型，以在支架植入动脉后立即防止血液凝固，并在长期内防止血管狭窄。由于MOFs中存在可水解官能团，在各种条件下的降解试验表明这些支架具有高度的生物可降解性。此外，MOF复合不会损害机械强度或柔韧性。这里描述的系统有望在宏观治疗诊断一体化器件中实现许多生物医学应用。使用MOF@PCL可以使医疗设备在MRI中可见，同时作为治疗剂的载体。
