Lu W, Kakemi M, Koizumi T
Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Japan.
J Pharmacobiodyn. 1988 Dec;11(12):794-800. doi: 10.1248/bpb1978.11.794.
In order to evaluate the effect of piretanide on the renal transport of water and osmotic substances, a clearance study was carried out in well hydrated rabbits. After intravenous bolus administration of piretanide, glomerular filtration rate, proximal tubular clearance and urine flow rate, as well as the pharmacokinetics of piretanide, were determined. A pharmacokinetic and pharmacodynamic link model which was developed in the previous paper was applied to the present experimental results. The results indicated that the effect of piretanide on the renal transport of water and osmotic substances in the hydrated rabbits was reasonably described by the model. The model analysis suggested that the diuretic response to piretanide was attributable to the inhibition of reabsorption of electrolytes in the proximal tubule, as well as in the loop of Henle.
为了评估吡咯他尼对水和渗透性物质肾脏转运的影响，在水分充足的家兔中进行了清除率研究。静脉推注吡咯他尼后，测定了肾小球滤过率、近端肾小管清除率和尿流率，以及吡咯他尼的药代动力学。将前一篇论文中建立的药代动力学和药效学联系模型应用于当前实验结果。结果表明，该模型能够合理地描述吡咯他尼对水分充足家兔肾脏水和渗透性物质转运的影响。模型分析表明，吡咯他尼的利尿反应归因于近端小管以及髓袢中电解质重吸收的抑制。
