Cuvelier R, Pellegrin P, Lesne M, van Ypersele de Strihou C
Eur J Clin Pharmacol. 1986;31 Suppl:15-9. doi: 10.1007/BF00541462.
The effect of torasemide, a new orally and parenterally active diuretic agent, on the renal mechanisms of dilution and concentration was studied in 6 healthy volunteers. The experimental conditions included water and osmotic diuresis. Torasemide caused maximal chloruresis and natriuresis during the 20-40 min after administration. The effect was more pronounced under osmotic diuresis and persisted throughout the 100 min of those experiments. A distinct effect both on free water clearance (CLH2O) during water diuresis and tubular reabsorption of solute free water (TcH2O) during osmotic diuresis strongly suggests that the major site of action of torasemide is the ascending limb of the loop of Henle. Comparison with furosemide under osmotic diuresis indicates longer abolition of TcH2O/GFR by torasemide in keeping with the fact that its half-life is 2- to 3-times longer than that of furosemide.
在6名健康志愿者中研究了新型口服和肠外活性利尿剂托拉塞米对肾脏稀释和浓缩机制的影响。实验条件包括水利尿和渗透性利尿。托拉塞米在给药后20 - 40分钟内引起最大程度的氯利尿和钠利尿。在渗透性利尿情况下该作用更明显，并且在这些实验的100分钟内持续存在。托拉塞米对水利尿期间的自由水清除率（CLH2O）以及渗透性利尿期间溶质自由水的肾小管重吸收（TcH2O）均有显著作用，这强烈表明托拉塞米的主要作用部位是髓袢升支。在渗透性利尿情况下与呋塞米比较表明，托拉塞米使TcH2O/GFR消除的时间更长，这与它的半衰期比呋塞米长2至3倍这一事实相符。
