常见基因变异与2型糖尿病风险
common genetic variant and type 2 diabetes mellitus risk.
作者信息
Erfani Taraneh, Sarhangi Negar, Afshari Mahdi, Abbasi Davood, Meybodi Hamid Reza Aghaei, Hasanzad Mandana
机构信息
Medical Genomics Research Center, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
Personalized Medicine Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
出版信息
J Diabetes Metab Disord. 2019 Dec 8;19(1):47-51. doi: 10.1007/s40200-019-00473-4. eCollection 2020 Jun.
BACKGROUND
Type 2 diabetes mellitus (T2DM) is a multifactorial trait that both environmental and genetic factors contribute to its pathogenesis. The most common single nucleotide polymorphism (SNP) of the gene, rs2237892, is highly associated with the risk of T2DM. The aim of the present study was to examine any association between gene rs2237892 variant and risk of T2DM in a group of Iranian patients.
METHODS
Genotyping was carried out in 100 type 2 diabetic patients and 100 non-diabetic subjects using the Sanger sequencing method.
RESULTS
The CC genotype caused more than 30% reduction in the risk of T2DM in compared with CT. Nonetheless, this association was not statistically significant and this variant had no protective effect for T2DM. A significant difference was not found in genotypes (CC, CT, and TT) and alleles (C and T) frequency of rs2237892 SNP between T2DM and control groups ( = 0.475 and = 0.470, respectively).
CONCLUSIONS
Our investigations did not show enough evidence for the presence of an association between gene rs2237892 polymorphism and risk of T2DM among a group of Iranian patients.
背景
2型糖尿病（T2DM）是一种多因素疾病，环境和遗传因素均参与其发病机制。该基因最常见的单核苷酸多态性（SNP），即rs2237892，与T2DM风险高度相关。本研究旨在探讨一组伊朗患者中该基因rs2237892变异与T2DM风险之间的关联。
方法
采用桑格测序法对100例2型糖尿病患者和100例非糖尿病受试者进行基因分型。
结果
与CT基因型相比，CC基因型使T2DM风险降低超过30%。然而，这种关联无统计学意义，该变异对T2DM无保护作用。T2DM组与对照组之间rs2237892 SNP的基因型（CC、CT和TT）及等位基因（C和T）频率无显著差异（分别为=0.475和=0.470）。
结论
我们的研究未显示足够证据表明一组伊朗患者中该基因rs2237892多态性与T2DM风险之间存在关联。
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