高剂量硫胺素补充剂可能会降低高血糖个体的静息能量消耗：一项随机、双盲交叉试验。
High-dose thiamine supplementation may reduce resting energy expenditure in individuals with hyperglycemia: a randomized, double - blind cross-over trial.
作者信息
Alaei-Shahmiri Fariba, Soares Mario J, Lahouti Maryam, Zhao Yun, Sherriff Jill
机构信息
Endocrine Research Center, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences (IUMS), No 10, Firouzeh St. Vali-Asr St., Tehran, Iran.
School of Public Health, Curtin University, Perth, Western Australia 6102 Australia.
出版信息
J Diabetes Metab Disord. 2020 Feb 22;19(1):297-304. doi: 10.1007/s40200-020-00508-1. eCollection 2020 Jun.
BACKGROUND
Despite the crucial role of thiamine in glucose and energy metabolism pathways, there has been no published study examining the impact of thiamine on energy metabolism in humans.
OBJECTIVE
To assess the effects of thiamine supplementation on resting energy expenditure (REE) in individuals with hyperglycemia.
METHODS
Twelve hyperglycemic patients completed this double-blind, randomized trial, where all participants received both thiamine (300 mg/day) and matched placebo for 6 weeks in a cross-over manner. REE was assessed by indirect calorimetry. Anthropometric measurements, fasting and 2-h plasma glucose, and glucose-induced thermogenesis were also assessed at the beginning and on the completion of each six-week phase.
RESULTS
Participants consuming thiamine supplements experienced a significant decrease in the REE assessed at week six compared to the baseline [mean (SE): 1478.93 (73.62) vs.1526.40 (73.46) kcal/d, = 0.02], and the placebo arm ( = 0.002). These results did not change significantly after adjusting for the participants' body weight and physical activity as potential confounders. Six-week intervention had no significant effect on the participants' body weight or waist circumference, in either supplement or placebo arms (all values>0.05). However, correlation analysis highlighted significant positive relationships between the changes in REE, and those in fasting (r = 0.497, = 0.019) and 2-h plasma glucose (r = 0.498, = 0.018) during the six-week intervention period.
CONCLUSION
Supplementation with high-dose thiamine may attenuate REE in patients with impaired glucose regulation. Our findings suggest that the impact of thiamine on REE may in part be explained by improved glycemic control.
TRIAL REGISTRATION
Australian New Zealand Clinical Trials Registry ACTRN12611000051943. https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?ACTRN=12611000051943.
背景
尽管硫胺素在葡萄糖和能量代谢途径中起着关键作用，但尚未有已发表的研究探讨硫胺素对人体能量代谢的影响。
目的
评估补充硫胺素对高血糖个体静息能量消耗（REE）的影响。
方法
12名高血糖患者完成了这项双盲随机试验，所有参与者均以交叉方式接受硫胺素（300毫克/天）和匹配的安慰剂，为期6周。通过间接测热法评估REE。在每个六周阶段开始和结束时，还评估了人体测量指标、空腹和餐后2小时血糖以及葡萄糖诱导的产热。
结果
与基线相比，服用硫胺素补充剂的参与者在第六周时评估的REE显著降低[平均值（标准误）：1478.93（73.62）千卡/天对1526.40（73.46）千卡/天，P = 0.02]，与安慰剂组相比也有显著差异（P = 0.002）。在将参与者的体重和身体活动作为潜在混杂因素进行调整后，这些结果没有显著变化。六周的干预对补充剂组或安慰剂组参与者的体重或腰围均无显著影响（所有P值>0.05）。然而，相关分析突出了六周干预期内REE变化与空腹血糖变化（r = 0.497，P = 0.019）和餐后2小时血糖变化（r = 0.498，P = 0.018）之间的显著正相关关系。
结论
补充高剂量硫胺素可能会降低血糖调节受损患者的REE。我们的研究结果表明，硫胺素对REE的影响部分可能是由于血糖控制改善所致。
试验注册
澳大利亚和新西兰临床试验注册中心ACTRN12611000051943。https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?ACTRN=12611000051943 。
Zotero 插件