卡瓦因可抑制人β-淀粉样蛋白诱导的麻痹。（你提供的原文似乎不完整，这里根据已有内容进行了合理补充翻译） - Suppr

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超能文献

Kavain suppresses human Aβ-induced paralysis in .

作者信息

Chamoli Manish, Chinta Shankar J, Andersen Julie K, Lithgow Gordon J

机构信息

Buck Instiute for Research on Aging, Novato, California, 94945 USA.

Touro University California, Vallejo, California, 94945 USA.

出版信息

MicroPubl Biol. 2020 May 21;2020. doi: 10.17912/micropub.biology.000254.

DOI:10.17912/micropub.biology.000254

PMID:32550490

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7252289/

Abstract

摘要

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Modulating calcium-mediated NFATc1 and mitogen-activated protein kinase deactivation underlies the inhibitory effects of kavain on osteoclastogenesis and bone resorption.卡瓦胡椒素对破骨细胞生成和骨吸收的抑制作用源于其对钙介导的 NFATc1 和丝裂原活化蛋白激酶失活的调节。

J Cell Physiol. 2018 Jan;234(1):789-801. doi: 10.1002/jcp.26893. Epub 2018 Aug 4.

Kavain Reduces Induced Adipocyte Inflammation: Role of PGC-1α Signaling.卡瓦胡椒素可减轻诱导性脂肪细胞炎症：PGC-1α 信号的作用。

J Immunol. 2018 Sep 1;201(5):1491-1499. doi: 10.4049/jimmunol.1800321. Epub 2018 Jul 23.

Kava for Generalized Anxiety Disorder: A Review of Current Evidence.卡瓦用于广泛性焦虑障碍：当前证据综述。

J Altern Complement Med. 2018 Aug;24(8):770-780. doi: 10.1089/acm.2018.0001. Epub 2018 Apr 11.

A Behavioral Survey of the Effects of Kavalactones on Neuromuscular Transmission.卡瓦内酯对神经肌肉传递影响的行为学调查

J Exp Neurosci. 2017 Jun 5;11:1179069517705384. doi: 10.1177/1179069517705384. eCollection 2017.

A Caenorhabditis elegans Model Elucidates a Conserved Role for TRPA1-Nrf Signaling in Reactive α-Dicarbonyl Detoxification.秀丽隐杆线虫模型揭示了TRPA1-Nrf信号通路在活性α-二羰基解毒中的保守作用。

Curr Biol. 2016 Nov 21;26(22):3014-3025. doi: 10.1016/j.cub.2016.09.024. Epub 2016 Oct 20.

Kavain Inhibition of LPS-Induced TNF-α via ERK/LITAF.卡瓦因通过ERK/LITAF抑制脂多糖诱导的肿瘤坏死因子-α

Toxicol Res (Camb). 2016 Jan 1;5(1):188-196. doi: 10.1039/C5TX00164A. Epub 2015 Oct 21.

Kavalactones, a novel class of protein glycation and lipid peroxidation inhibitors.卡瓦内酯，一类新型的蛋白质糖基化和脂质过氧化抑制剂。

Planta Med. 2014 Aug;80(12):1001-8. doi: 10.1055/s-0034-1382949. Epub 2014 Aug 6.

Glycation exacerbates the neuronal toxicity of β-amyloid.糖基化加剧了β-淀粉样蛋白的神经毒性。

Cell Death Dis. 2013 Jun 13;4(6):e673. doi: 10.1038/cddis.2013.180.

Utility of an improved model of amyloid-beta (Aβ₁₋₄₂) toxicity in Caenorhabditis elegans for drug screening for Alzheimer's disease.利用改良的淀粉样β（Aβ₁₋₄₂）毒性在秀丽隐杆线虫中进行阿尔茨海默病药物筛选的效用。

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