Gorman Lucy M, Judge Sarah J, Fezai Myriam, Jemaà Mohamed, Harris John B, Caldwell Gary S
School of Natural and Environmental Sciences, Newcastle University, Ridley Building, Claremont Road, Newcastle Upon Tyne, NE1 7RU, UK.
Medical Toxicology Centre, Newcastle University, Wolfson Building, Claremont Place, Newcastle Upon Tyne, NE2 4AA, UK.
Toxicon X. 2020 Feb 7;6:100025. doi: 10.1016/j.toxcx.2020.100025. eCollection 2020 Jun.
In comparison with other animal venoms, fish venoms remain relatively understudied. This is especially true for that of the lesser and greater weever fish which, apart from the isolation of their unique venom cytolysins, trachinine and dracotoxin, respectively, remain relatively uncharacterised. Envenomation reports mainly include mild symptoms consisting of nociception and inflammation. However, like most fish venoms, if the venom becomes systemic it causes cardiorespiratory and blood pressure changes. Although venom has not been studied since the 1990's, recent studies on venom have discovered novel cytotoxic components on human cancer cells, but due to the scarcity of research on the molecular make-up of the venom, the molecule(s) causing this cytotoxicity remains unknown. This review analyses past studies on and venom, the methods used in the , the venom constituents characterised, the reported symptoms of envenomation and compares these findings with those from other venomous Scorpaeniformes.
与其他动物毒液相比,鱼类毒液的研究相对较少。对于小及大牙鲆鱼的毒液来说尤其如此,除了分别分离出它们独特的毒液溶细胞素、龙介鱼毒素和龙毒素外,其毒液仍相对缺乏特征描述。蜇伤报告主要包括由疼痛和炎症组成的轻微症状。然而,与大多数鱼类毒液一样,如果毒液进入全身循环,就会导致心肺和血压变化。尽管自20世纪90年代以来就没有对该毒液进行过研究,但最近对该毒液的研究发现了对人类癌细胞有新型细胞毒性的成分,但由于对毒液分子组成的研究稀缺,导致这种细胞毒性的分子仍不为人知。这篇综述分析了过去关于该毒液和该毒液的研究、研究中使用的方法、已鉴定的毒液成分、报告的蜇伤症状,并将这些发现与其他有毒鲉形目鱼类的发现进行了比较。