Kamişli Özden, Tecellioğlu Mehmet, Erbay Mehmet Fatih, Kamişli Suat, Özcan Cemal
Department of Neurology, İnönü University School of Medicine, Malatya, Turkey.
Department of Radiology, İnönü University School of Medicine, Malatya, Turkey.
Noro Psikiyatr Ars. 2017 Nov 8;57(2):160-164. doi: 10.5152/npa.2017.22732. eCollection 2020 Jun.
Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) is an inflammatory disorder of the central nervous system. The pathophysiology of CLIPPERS is unknown. The disease has characteristic radiological lesions located in the pons, bulbus, and cerebellum. Here we report two new cases and review the literature on CLIPPERS syndrome. A 35-year-old woman presented with a 2-month history of progressive double vision, vertigo, gait ataxia, nausea, and vomiting. The second case was that of a 40-year-old Iraqi man who presented with a 3-month history of vertigo, headache, and gait ataxia. Diagnosis of CLIPPERS was established based on findings of punctate, nodular enhancing lesions in the pons and bulbus in the first case and in the cerebellum in the second. Our patients responded well to steroid therapy and remained relapse-free for 2 years. CLIPPERS is a rare autoimmune disorder with characteristic radiological findings. Long-term immunosuppressive therapy is necessary for treatment.
对类固醇有反应的桥脑周围血管增强的慢性淋巴细胞性炎症（CLIPPERS）是一种中枢神经系统炎症性疾病。CLIPPERS的病理生理学尚不清楚。该疾病在脑桥、延髓和小脑有特征性的放射学病变。在此我们报告两例新病例并回顾CLIPPERS综合征的相关文献。一名35岁女性有2个月进行性复视、眩晕、步态共济失调、恶心和呕吐的病史。第二例是一名40岁伊拉克男性，有3个月眩晕、头痛和步态共济失调的病史。根据第一例在脑桥和延髓发现点状、结节状强化病变以及第二例在小脑发现此类病变而确诊为CLIPPERS。我们的患者对类固醇治疗反应良好，且2年无复发。CLIPPERS是一种具有特征性放射学表现的罕见自身免疫性疾病。长期免疫抑制治疗是必要的。
