Mehrnahad Mersad, Kord Ali, Rezaei Zahra, Kord Reza
Department of Radiology, Arak University of Medical Sciences, 1 A'lam-Al-Hoda Street, PO Box (646), Arak 3819693345, Iran.
Division of Interventional Radiology, Department of Diagnostic Radiology, University of Illinois College of Medicine, Chicago, IL, USA.
Radiol Case Rep. 2020 Jun 9;15(8):1189-1193. doi: 10.1016/j.radcr.2020.05.021. eCollection 2020 Aug.
Generalized lymphangiomatosis (GLA) is a rare lymphatic abnormality, mostly affects children and young individuals and can be a diagnostic challenge because of wide spectrum of clinical manifestations. A 26-year-old woman presented to the emergency department of our institution with respiratory distress and hypoxia. The patient reported similar episodes for the past 10 years without a definite diagnosis. The imaging study demonstrated findings suggestive of GLA with pulmonary, retroperitoneal and osseous involvements which was confirmed on pathological studies from a lung biopsy. A concise review of the clinical, imaging and pathological findings of GLA is provided in this study. A comprehensive history and physical examination, laboratory and pathological work up and imaging is required to make the diagnosis of GLA. The characteristic imaging findings play an essential role to rule out other possible diagnoses and raise the possibility of GLA.
泛发性淋巴管瘤病（GLA）是一种罕见的淋巴管异常疾病，主要影响儿童和年轻人，由于其临床表现多样，诊断具有挑战性。一名26岁女性因呼吸窘迫和缺氧就诊于我院急诊科。患者自述在过去10年中有类似发作，但未明确诊断。影像学检查显示有提示GLA伴肺、腹膜后和骨骼受累的表现，经肺活检病理检查得以证实。本研究对GLA的临床、影像学和病理表现进行了简要综述。诊断GLA需要全面的病史、体格检查、实验室及病理检查以及影像学检查。特征性的影像学表现对于排除其他可能的诊断并提高GLA的可能性起着至关重要的作用。
