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Emerging therapies in acute ischemic stroke.急性缺血性卒中的新兴疗法
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2
Comparison of non-stent retriever and stent retriever mechanical thrombectomy devices for the endovascular treatment of acute ischemic stroke.比较非取栓支架和取栓支架机械血栓切除术装置在急性缺血性脑卒中血管内治疗中的应用。
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TREVO stent-retriever mechanical thrombectomy for acute ischemic stroke secondary to large vessel occlusion registry.雷沃（ Trevo ）支架取栓机械血栓切除术治疗大动脉闭塞性急性缺血性脑卒中登记研究。
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Adjuvant intra-arterial rt-PA injection at the initially deployed solitaire stent enhances the efficacy of mechanical thrombectomy in acute ischemic stroke.在最初放置的 Solitaire 支架内进行辅助动脉内 rt-PA 注射可提高急性缺血性脑卒中机械取栓的疗效。
J Neurol Sci. 2018 Mar 15;386:69-73. doi: 10.1016/j.jns.2018.01.012. Epub 2018 Jan 10.
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本文引用的文献

1
Efficacy and safety of nerinetide for the treatment of acute ischaemic stroke (ESCAPE-NA1): a multicentre, double-blind, randomised controlled trial.尼替西农治疗急性缺血性脑卒中的疗效和安全性（ESCAPE-NA1）：一项多中心、双盲、随机对照试验。
Lancet. 2020 Mar 14;395(10227):878-887. doi: 10.1016/S0140-6736(20)30258-0. Epub 2020 Feb 20.
2
Medical Management vs Mechanical Thrombectomy for Mild Strokes: An International Multicenter Study and Systematic Review and Meta-analysis.轻卒中型中风的药物治疗与机械取栓治疗的对比：一项国际性多中心研究及系统回顾和荟萃分析。
JAMA Neurol. 2020 Jan 1;77(1):16-24. doi: 10.1001/jamaneurol.2019.3112.
3
Outcomes of Endovascular Thrombectomy vs Medical Management Alone in Patients With Large Ischemic Cores: A Secondary Analysis of the Optimizing Patient's Selection for Endovascular Treatment in Acute Ischemic Stroke (SELECT) Study.大缺血核心患者血管内血栓切除术与单纯药物治疗的疗效比较：急性缺血性卒中血管内治疗患者选择优化（SELECT）研究的二次分析
JAMA Neurol. 2019 Oct 1;76(10):1147-1156. doi: 10.1001/jamaneurol.2019.2109.
4
Intensive vs Standard Treatment of Hyperglycemia and Functional Outcome in Patients With Acute Ischemic Stroke: The SHINE Randomized Clinical Trial.强化与标准血糖控制对急性缺血性脑卒中患者功能结局的影响：SHINE 随机临床试验。
JAMA. 2019 Jul 23;322(4):326-335. doi: 10.1001/jama.2019.9346.
5
Thrombolysis Guided by Perfusion Imaging up to 9 Hours after Onset of Stroke.发病 9 小时内采用灌注成像指导的溶栓治疗。
N Engl J Med. 2019 May 9;380(19):1795-1803. doi: 10.1056/NEJMoa1813046.
6
Aspiration thrombectomy versus stent retriever thrombectomy as first-line approach for large vessel occlusion (COMPASS): a multicentre, randomised, open label, blinded outcome, non-inferiority trial.抽吸血栓切除术与支架取栓术作为血管内治疗大动脉闭塞（COMPASS）的一线治疗方法：一项多中心、随机、开放标签、盲法结局、非劣效性试验。
Lancet. 2019 Mar 9;393(10175):998-1008. doi: 10.1016/S0140-6736(19)30297-1.
7
Intensive blood pressure reduction with intravenous thrombolysis therapy for acute ischaemic stroke (ENCHANTED): an international, randomised, open-label, blinded-endpoint, phase 3 trial.急性缺血性脑卒中静脉溶栓治疗的强化降压（ENCHANTED）试验：一项国际、随机、开放标签、盲终点、3 期临床试验。
Lancet. 2019 Mar 2;393(10174):877-888. doi: 10.1016/S0140-6736(19)30038-8. Epub 2019 Feb 7.
8
Real-World Treatment Trends in Endovascular Stroke Therapy.真实世界中血管内卒中治疗的趋势。
Stroke. 2019 Mar;50(3):683-689. doi: 10.1161/STROKEAHA.118.023967.
9
Systematic review of organizational models for intra-arterial treatment of acute ischemic stroke.急性缺血性脑卒中动脉内治疗的组织模式系统评价。
Int J Stroke. 2019 Jan;14(1):12-22. doi: 10.1177/1747493018806157. Epub 2018 Oct 10.
10
Single-center experience with the Tigertriever device for the recanalization of large vessel occlusions in acute ischemic stroke.单中心使用 Tigertriever 装置治疗急性缺血性脑卒中的大血管闭塞。
J Neurointerv Surg. 2019 May;11(5):455-459. doi: 10.1136/neurintsurg-2018-014196. Epub 2018 Sep 27.

急性缺血性卒中的新兴疗法

Emerging therapies in acute ischemic stroke.

作者信息

Liaw Nicholas, Liebeskind David

机构信息

Department of Vascular Neurology, University of California, Los Angeles, 635 Charles E Young Drive South, Suite 225, Los Angeles, California, 90095-7334, USA.

出版信息

F1000Res. 2020 Jun 5;9. doi: 10.12688/f1000research.21100.1. eCollection 2020.

DOI:10.12688/f1000research.21100.1
PMID:32551094
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7276937/
Abstract

Thrombolysis and mechanical thrombectomy have revolutionized the care of patients with acute ischemic stroke. The number of patients who can benefit from these treatments continues to increase as new studies demonstrate that not just time since stroke onset but also collateral circulation influences outcome. Technologies such as telestroke, mobile stroke units, and artificial intelligence are playing an increasing role in identifying and treating stroke. Stroke-systems-of-care models continue to streamline the delivery of definitive revascularization in the age of mechanical thrombectomy.

摘要

溶栓和机械取栓彻底改变了急性缺血性脑卒中患者的治疗方式。随着新研究表明，不仅卒中发作后的时间，而且侧支循环也会影响预后，能够从这些治疗中获益的患者数量持续增加。远程卒中、移动卒中单元和人工智能等技术在识别和治疗卒中方面发挥着越来越重要的作用。在机械取栓时代，卒中医疗系统模式继续简化确定性血管重建的实施。