Jakob Heinz, Idhrees Mohammed, Bashir Mohamad
Department of Thoracic and Cardiovascular Surgery, West German Heart Center Essen, University Hospital Essen, Essen, Germany.
Institute of Cardiac and Aortic Disorders, SRM Institutes for Medical Science (SIMS Hospital), Chennai, India.
Ann Cardiothorac Surg. 2020 May;9(3):164-169. doi: 10.21037/acs-2020-fet-60.
We present a recapitulation of 15 years of experience starting with conception, inception, development, and clinical implementation and application of the E-vita open hybrid graft. Concomitantly, we delve into surgical techniques that shaped our clinical results. Introduced in February 2005, the novel "Essen I Prosthesis", was first-in-human surgically implanted. Follow on to this success, and within six months, eight further applications were performed. Once, the CE mark was attained, the prosthesis was branded as E-vita Open Prosthesis. In 2008, the blood-tight modification was introduced, and with time and clinical practice and application, the device's indications were expanded. Hence, the focus remained on managing complex thoracic aneurysmal disease and in particular acute and chronic type I aortic dissections. With the surge of our surgical experience and the integration of various surgical modifications, 30-days mortality was reduced to 12%, while morbidities such as stroke and spinal cord injury were reduced to 7% and 3%, respectively. The rate of re-intervention on distal aorta was significantly reduced; an attestation to the prosthesis's effectuated performance which contrasted proximal aortic repairs. With new additional device variations on the horizon, a wider range of patient-specific treatment options can now be offered.
我们回顾了15年来从构思、初创、开发到E-vita开放式杂交移植物的临床实施与应用的经验。同时,我们深入探讨了塑造我们临床结果的手术技术。2005年2月推出的新型“埃森I型假体”首次在人体进行手术植入。在此成功之后,六个月内又进行了八次应用。一旦获得CE标志,该假体就被命名为E-vita开放式假体。2008年,引入了血密性改进,随着时间的推移以及临床实践与应用,该设备的适应症得以扩大。因此,重点仍然是管理复杂的胸主动脉瘤疾病,特别是急性和慢性I型主动脉夹层。随着我们手术经验的增加以及各种手术改进的整合,30天死亡率降至12%,而中风和脊髓损伤等并发症分别降至7%和3%。远端主动脉再次干预的发生率显著降低;这证明了该假体的有效性能,与近端主动脉修复形成对比。随着即将出现新的额外设备变体,现在可以提供更广泛的针对患者的治疗选择。