Jaiswal Amit Kumar, Chaudhary Shatdal
Department of Internal Medicine, Siddhartha Nagar City Hospital, Bhairahawa, Nepal.
Department of Internal Medicine, Universal College of Medical Sciences, Bhairahawa, Nepal.
Adv Med. 2020 May 30;2020:1234341. doi: 10.1155/2020/1234341. eCollection 2020.
Colonoscopy is considered as a gold standard investigation for screening of colorectal cancer and other lower gastrointestinal pathologies. Adequate bowel preparation is absolutely necessary for a fruitful colonoscopy. Various bowel cleansing agents are being used for his purpose. The aim of the present study was to compare the two bowel cleansing agents: a single dose of Polyethylene Glycol (PEG) solution and a split dose of Sodium Picosulfate (Na PICOSUL) tablet with regards to cleansing efficacy and tolerability among the patients scheduled for colonoscopy.
It is an open-label hospital-based observational study. A total of sixty-four patients were grouped randomly into two groups of bowel cleansing agents that are PEG and Na PICOSUL during the study period between 1 December 2015 and 30 November 2016. Patients' tolerability was evaluated using a structured questionnaire, and the bowel cleansing efficacy was evaluated using the Aronchick Bowel Preparation Scale (ABPS).
The group that received PEG solution was found to have better efficacy than that which received Na PICOSUL tablet (63.3% versus 29.4%, respectively, with a value < 0.028) with excellent grade as per ABPS. The Na PICOSUL group was found better in terms of tolerability than the PEG group as nausea/vomiting was encountered significantly higher in the PEG group than in the Na PICOSUL group (43.3% versus 11.8%, respectively, with a value < 0.01).
Colonic preparation with a split dose of Na PICOSUL tablet was better tolerated than the evening before regimen of PEG solution. However, PEG solution was found to be more efficacious in bowel cleansing, but procedural performance and lesion detection were similar for both agents.
结肠镜检查被认为是筛查结直肠癌和其他下消化道疾病的金标准检查方法。充分的肠道准备对于成功的结肠镜检查绝对必要。为此使用了各种肠道清洁剂。本研究的目的是比较两种肠道清洁剂：单剂量聚乙二醇（PEG）溶液和分次剂量的匹可硫酸钠（Na PICOSUL）片剂，比较其在结肠镜检查患者中的清洁效果和耐受性。
这是一项基于医院的开放标签观察性研究。在2015年12月1日至2016年11月30日的研究期间，共有64例患者被随机分为两组肠道清洁剂组，即PEG组和Na PICOSUL组。使用结构化问卷评估患者的耐受性，并使用阿龙奇克肠道准备量表（ABPS）评估肠道清洁效果。
发现接受PEG溶液的组比接受Na PICOSUL片剂的组具有更好的效果（分别为63.3%和29.4%，P值<0.028），根据ABPS为优秀等级。发现Na PICOSUL组在耐受性方面比PEG组更好，因为PEG组中恶心/呕吐的发生率明显高于Na PICOSUL组（分别为43.3%和11.8%，P值<0.01）。
分次剂量的Na PICOSUL片剂进行结肠准备比PEG溶液的前夜方案耐受性更好。然而，发现PEG溶液在肠道清洁方面更有效，但两种制剂的操作表现和病变检测相似。
