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基因伊甸-VIR和诺维林对严重急性呼吸综合征冠状病毒的作用:对2019冠状病毒病的启示。

Effects of Gene-Eden-VIR and Novirin on SARS-CoV: Implications for COVID-19.

作者信息

Polansky Hanan, Lori Gillad

机构信息

The Center for the Biology of Chronic Disease, Valley Cottage, NY, USA.

出版信息

J Evid Based Integr Med. 2020 Jan-Dec;25:2515690X20932523. doi: 10.1177/2515690X20932523.

DOI:10.1177/2515690X20932523
PMID:32551855
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7303500/
Abstract

The coronavirus (SARS-CoV-2), which causes COVID-19, is a betacoronavirus closely related to the human severe acute respiratory syndrome (SARS)-coronavirus (SARS-CoV). The recent COVID-19 outbreak created an urgent need for treatment. To expedite the development of such treatment, pharmaceutical companies and government agencies are currently testing several existing drugs for their effect on the virus. Gene-Eden-VIR and Novirin are natural, broad-spectrum, antiviral treatments proven to be safe and effective in several clinical studies. In this article, we present evidence indicating that the 5 Gene-Eden-VIR/Novirin ingredients have anti-betacoronavirus, and specifically, anti-SARS-CoV effects. We consider this evidence as a first indication of the anti-coronavirus effects of Gene-Eden-VIR/Novirin. Next, we are planning to conduct a clinical study with users of the treatments to test the effects of Gene-Eden-VIR/Novirin on individuals at risk and those infected with the virus.

摘要

导致新冠肺炎的冠状病毒(SARS-CoV-2)是一种与人类严重急性呼吸综合征(SARS)冠状病毒(SARS-CoV)密切相关的β冠状病毒。近期新冠肺炎疫情的爆发使得对治疗方法产生了迫切需求。为加快此类治疗方法的研发,制药公司和政府机构目前正在测试几种现有药物对该病毒的作用。Gene-Eden-VIR和诺维琳是天然的广谱抗病毒疗法,已在多项临床研究中被证明是安全有效的。在本文中,我们提供证据表明Gene-Eden-VIR/诺维琳的5种成分具有抗β冠状病毒的作用,具体而言,具有抗SARS-CoV的作用。我们将此证据视为Gene-Eden-VIR/诺维琳具有抗冠状病毒作用的首个迹象。接下来,我们计划对这些疗法的使用者进行一项临床研究,以测试Gene-Eden-VIR/诺维琳对有感染风险的个体以及感染该病毒的个体的作用。

相似文献

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Effects of Gene-Eden-VIR and Novirin on SARS-CoV: Implications for COVID-19.基因伊甸-VIR和诺维林对严重急性呼吸综合征冠状病毒的作用:对2019冠状病毒病的启示。
J Evid Based Integr Med. 2020 Jan-Dec;25:2515690X20932523. doi: 10.1177/2515690X20932523.
2
Coronavirus disease 2019 (COVID-19): first indication of efficacy of Gene-Eden-VIR/Novirin in SARS-CoV-2 infection.2019冠状病毒病(COVID-19):基因伊甸园-VIR/诺维林对严重急性呼吸综合征冠状病毒2感染疗效的首个迹象。
Int J Antimicrob Agents. 2020 Jun;55(6):105971. doi: 10.1016/j.ijantimicag.2020.105971. Epub 2020 Apr 10.
3
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Med Hypotheses. 2020 Sep;142:109822. doi: 10.1016/j.mehy.2020.109822. Epub 2020 May 7.
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Med Sci (Paris). 2020 Jun-Jul;36(6-7):555-558. doi: 10.1051/medsci/2020106. Epub 2020 Jun 19.
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Novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) co-infection with HIV: clinical case series analysis in North Central Nigeria.新型严重急性呼吸综合征冠状病毒2(SARS-CoV-2)与HIV合并感染:尼日利亚中北部的临床病例系列分析
Pan Afr Med J. 2020 Sep 10;37:47. doi: 10.11604/pamj.2020.37.47.24200. eCollection 2020.

本文引用的文献

1
Breadth of concomitant immune responses prior to patient recovery: a case report of non-severe COVID-19.患者康复前伴随免疫反应的广度:非重症COVID-19病例报告
Nat Med. 2020 Apr;26(4):453-455. doi: 10.1038/s41591-020-0819-2.
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Breakthrough: Chloroquine phosphate has shown apparent efficacy in treatment of COVID-19 associated pneumonia in clinical studies.突破:磷酸氯喹在临床研究中显示出对 COVID-19 相关肺炎的明显疗效。
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Case of the Index Patient Who Caused Tertiary Transmission of COVID-19 Infection in Korea: the Application of Lopinavir/Ritonavir for the Treatment of COVID-19 Infected Pneumonia Monitored by Quantitative RT-PCR.韩国第三代 COVID-19 感染传播者索引患者病例:应用洛匹那韦/利托那韦定量 RT-PCR 监测 COVID-19 感染肺炎的治疗。
J Korean Med Sci. 2020 Feb 17;35(6):e79. doi: 10.3346/jkms.2020.35.e79.
4
Genomic variance of the 2019-nCoV coronavirus.2019-nCoV 冠状病毒的基因组变异。
J Med Virol. 2020 May;92(5):522-528. doi: 10.1002/jmv.25700. Epub 2020 Feb 19.
5
A pneumonia outbreak associated with a new coronavirus of probable bat origin.一种新型冠状病毒引发的肺炎疫情,该病毒可能来源于蝙蝠。
Nature. 2020 Mar;579(7798):270-273. doi: 10.1038/s41586-020-2012-7. Epub 2020 Feb 3.
6
Preliminary estimation of the basic reproduction number of novel coronavirus (2019-nCoV) in China, from 2019 to 2020: A data-driven analysis in the early phase of the outbreak.2019 年至 2020 年中国新型冠状病毒(2019-nCoV)基本繁殖数的初步估计:疫情早期的基于数据的分析。
Int J Infect Dis. 2020 Mar;92:214-217. doi: 10.1016/j.ijid.2020.01.050. Epub 2020 Jan 30.
7
Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding.新冠病毒的基因组特征和流行病学:对病毒起源和受体结合的影响。
Lancet. 2020 Feb 22;395(10224):565-574. doi: 10.1016/S0140-6736(20)30251-8. Epub 2020 Jan 30.
8
Selenium, Selenoproteins and Viral Infection.硒、硒蛋白与病毒感染。
Nutrients. 2019 Sep 4;11(9):2101. doi: 10.3390/nu11092101.
9
Immunomodulatory Effects of Flavonoids: Possible Induction of T CD4+ Regulatory Cells Through Suppression of mTOR Pathway Signaling Activity.黄酮类化合物的免疫调节作用:通过抑制 mTOR 通路信号活性诱导 T CD4+ 调节细胞。
Front Immunol. 2019 Jan 31;10:51. doi: 10.3389/fimmu.2019.00051. eCollection 2019.
10
Clinical Trial of Herbal Treatment Gene-Eden-VIR/Novirin in Oral Herpes.草药治疗药物Gene-Eden-VIR/Novirin用于口腔疱疹的临床试验
J Evid Based Integr Med. 2018 Jan-Dec;23:2515690X18806269. doi: 10.1177/2515690X18806269.