Stone E A, Freedman L S, Morgano L E
Pharmacol Biochem Behav. 1978 Oct;9(4):551-3. doi: 10.1016/0091-3057(78)90057-6.
Rats subjected to 9 daily sessions of electric footshock stress showed marked increases in tyrosine hydroxylase activity in various brain regions and in the adrenal gland. The activity of the brain enzyme was elevated in the cerebral cortex, hypothalamus, locus coeruleus and the pons-medulla indicating a widespread effect of stress throughout the brain. Anatomical specificity of the response was indicated by a greater percent increase in the locus coeruleus, a nucleus containing noradrenergic cell bodies, than in the hypothalamus, cortex and pons-medulla, areas that contain noradrenergic terminals.
每天接受9次电休克应激的大鼠，其大脑各区域和肾上腺中的酪氨酸羟化酶活性显著增加。大脑酶的活性在大脑皮层、下丘脑、蓝斑和脑桥延髓中升高，表明应激在整个大脑中具有广泛影响。蓝斑（一个含有去甲肾上腺素能细胞体的核团）的反应增加百分比高于下丘脑、皮层和脑桥延髓（含有去甲肾上腺素能终末的区域），这表明了反应的解剖学特异性。
