Department of Cardiothoracic Surgery, Zhuhai People's Hospital, Zhuhai Hospital Affiliated with Jinan University, Zhuhai, China.
Physical Examination Center, Affiliated People's Hospital of Jiangsu University, Zhenjiang, Jiangsu Province, China.
Immunol Invest. 2021 Jul;50(5):461-477. doi: 10.1080/08820139.2020.1776726. Epub 2020 Jun 18.
Inflammatory and inducible chemokines are the hallmarks of malignancy. Monocyte chemo-attractant protein-1 (MCP-1) is a crucial chemokine implicated in infection and inflammation. : We performed an updated meta-analysis of thirty independent case-control studies with 6,777 cancer cases and 7,840 controls to determine if the gene rs1024611 A > G variant is associated with the risk of cancer. : The G allele carriers of rs1024611 in the gene might have a null association with cancer risk in overall comparison. In a subgroup analysis by ethnicity, we identified a marked association between the G allele rs1024611 polymorphism and cancer risk in the Caucasian populations (GG . AA: OR = 1.72, 95% CI, 1.12-2.64, = .013, and GG . AG/AA: OR = 1.82, 95% CI, 1.19-2.78, = .006). The potential bias in literature selection was witnessed in this meta-analysis (G . A: = 0.187, = 0.049; and GG/GA . AA: = 0.069, = 0.024). The adjusted ORs and CIs of the nonparametric "trim-and-fill" method demonstrated the reliability of these findings. The outcome of heterogeneity analysis indicated that heterogeneity might be due to small sample sizes (<1000 subjects), cancer types (bladder cancer, other cancers), ethnicity (Asians), and population-based studies. However, the sensitivity analysis validated the reliability of the findings. : In conclusion, this updated meta-analysis showed that the G carrier of the gene rs1024611 is associated with susceptibility to cancer in Caucasian.
炎症和诱导型趋化因子是恶性肿瘤的特征。单核细胞趋化蛋白-1（MCP-1）是一种关键的趋化因子，与感染和炎症有关。我们对 30 项独立的病例对照研究进行了更新的荟萃分析，共有 6777 例癌症病例和 7840 例对照，以确定基因 rs1024611 的 A > G 变体是否与癌症风险相关。基因 rs1024611 的 G 等位基因携带者在总体比较中与癌症风险可能没有关联。在按种族进行的亚组分析中，我们发现基因 rs1024611 的 G 等位基因多态性与高加索人群的癌症风险之间存在显著关联（GG. AA：OR = 1.72，95%CI，1.12-2.64，P =.013，GG. AG/AA：OR = 1.82，95%CI，1.19-2.78，P =.006）。这项荟萃分析中观察到文献选择的潜在偏倚（G. A：P = 0.187，P = 0.049；GG/GA. AA：P = 0.069，P = 0.024）。非参数“修剪和填充”方法的调整后的 OR 和 CIs 证明了这些发现的可靠性。异质性分析的结果表明，异质性可能是由于样本量较小（<1000 例）、癌症类型（膀胱癌、其他癌症）、种族（亚洲人）和基于人群的研究。然而，敏感性分析验证了这些发现的可靠性。总之，这项更新的荟萃分析表明，基因 rs1024611 的 G 携带者与高加索人群的癌症易感性相关。
