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High doses of ketamine to improve neuronal edema in subarachnoid hemorrhage: we should consider other undesirable organ targets.高剂量氯胺酮改善蛛网膜下腔出血中的神经元水肿：我们应考虑其他不良器官靶点。
Crit Care. 2020 Jun 18;24(1):362. doi: 10.1186/s13054-020-03004-3.
2
Spreading Depolarization during the Acute Stage of Experimental Subarachnoid Hemorrhage in Mice.小鼠实验性蛛网膜下腔出血急性期的扩散性去极化
Acta Neurochir Suppl. 2020;127:97-103. doi: 10.1007/978-3-030-04615-6_16.
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Sedation of Patients with Acute Aneurysmal Subarachnoid Hemorrhage with Ketamine Is Safe and Might Influence the Occurrence of Cerebral Infarctions Associated with Delayed Cerebral Ischemia.氯胺酮用于急性动脉瘤性蛛网膜下腔出血患者的镇静是安全的，且可能影响与迟发性脑缺血相关的脑梗死的发生。
World Neurosurg. 2017 Jan;97:374-382. doi: 10.1016/j.wneu.2016.09.121. Epub 2016 Oct 11.
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Neurogenic pulmonary edema and large negative T waves associated with subarachnoid hemorrhage.神经源性肺水肿及与蛛网膜下腔出血相关的巨大负向T波。
Intern Med. 2001 Aug;40(8):826-8. doi: 10.2169/internalmedicine.40.826.
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The Role of Intracranial Pressure and Subarachnoid Blood Clots in Early Brain Injury After Experimental Subarachnoid Hemorrhage in Rats.颅内压和蛛网膜下腔血红细胞在大鼠实验性蛛网膜下腔出血后早期脑损伤中的作用。
World Neurosurg. 2019 Sep;129:e63-e72. doi: 10.1016/j.wneu.2019.05.009. Epub 2019 May 15.
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The effect of nimodipine monotherapy and combined treatment with ketamine and lignocaine in aneurysmal subarachnoid haemorrhage.尼莫地平单一疗法以及氯胺酮与利多卡因联合治疗对动脉瘤性蛛网膜下腔出血的影响。
J Int Med Res. 1996 Sep-Oct;24(5):425-32. doi: 10.1177/030006059602400504.
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A multicenter prospective cohort study of volume management after subarachnoid hemorrhage: circulatory characteristics of pulmonary edema after subarachnoid hemorrhage.一项蛛网膜下腔出血后容量管理的多中心前瞻性队列研究：蛛网膜下腔出血后肺水肿的循环特征。
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Optimal range of global end-diastolic volume for fluid management after aneurysmal subarachnoid hemorrhage: a multicenter prospective cohort study.最佳的全球舒张末期容积范围用于动脉瘤性蛛网膜下腔出血后的液体管理：一项多中心前瞻性队列研究。
Crit Care Med. 2014 Jun;42(6):1348-56. doi: 10.1097/CCM.0000000000000163.
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Focal brain edema and natriuretic peptides in patients with subarachnoid hemorrhage.
Acta Neurochir Suppl. 2003;86:489-91. doi: 10.1007/978-3-7091-0651-8_100.
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Mechanisms of Global Cerebral Edema Formation in Aneurysmal Subarachnoid Hemorrhage.动脉瘤性蛛网膜下腔出血中全脑水肿形成的机制
Neurocrit Care. 2017 Apr;26(2):301-310. doi: 10.1007/s12028-016-0354-7.

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Ketamine-induced prevention of SD-associated late infarct progression in experimental ischemia.氯胺酮诱导预防实验性缺血中与睡眠剥夺相关的晚期梗死进展。
Sci Rep. 2024 May 3;14(1):10186. doi: 10.1038/s41598-024-59835-5.
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Questioning Glutamate Excitotoxicity in Acute Brain Damage: The Importance of Spreading Depolarization.质疑急性脑损伤中的谷氨酸兴奋性毒性：去极化波传播的重要性。
Neurocrit Care. 2022 Jun;37(Suppl 1):11-30. doi: 10.1007/s12028-021-01429-4. Epub 2022 Feb 22.

本文引用的文献

1
Lasting s-ketamine block of spreading depolarizations in subarachnoid hemorrhage: a retrospective cohort study.蛛网膜下腔出血中持续的 S-氯胺酮阻断扩散去极化：一项回顾性队列研究。
Crit Care. 2019 Dec 30;23(1):427. doi: 10.1186/s13054-019-2711-3.
2
Sedation of Patients with Acute Aneurysmal Subarachnoid Hemorrhage with Ketamine Is Safe and Might Influence the Occurrence of Cerebral Infarctions Associated with Delayed Cerebral Ischemia.氯胺酮用于急性动脉瘤性蛛网膜下腔出血患者的镇静是安全的，且可能影响与迟发性脑缺血相关的脑梗死的发生。
World Neurosurg. 2017 Jan;97:374-382. doi: 10.1016/j.wneu.2016.09.121. Epub 2016 Oct 11.
3
Complications in Aneurysmal Subarachnoid Hemorrhage Patients With and Without Subdural Electrode Strip for Electrocorticography.有和没有用于皮质脑电图的硬膜下电极条的动脉瘤性蛛网膜下腔出血患者的并发症
J Clin Neurophysiol. 2016 Jun;33(3):250-9. doi: 10.1097/WNP.0000000000000274.
4
Ischemic Postconditioning and Subanesthetic S(+)-Ketamine Infusion: Effects on Renal Function and Histology in Rats.缺血后处理与亚麻醉剂量S(+)-氯胺酮输注：对大鼠肾功能和组织学的影响
Biomed Res Int. 2015;2015:864902. doi: 10.1155/2015/864902. Epub 2015 Aug 27.
5
The role of spreading depression, spreading depolarization and spreading ischemia in neurological disease.扩散性抑制、扩散性去极化和扩散性缺血在神经疾病中的作用。
Nat Med. 2011 Apr;17(4):439-47. doi: 10.1038/nm.2333. Epub 2011 Apr 7.
6
Acute Kidney Injury Network: report of an initiative to improve outcomes in acute kidney injury.急性肾损伤网络：改善急性肾损伤预后的倡议报告
Crit Care. 2007;11(2):R31. doi: 10.1186/cc5713.
7
Influence of S(+)-ketamine analgesia in renal intraoperative ischemia: histological study in rats.S(+)-氯胺酮镇痛对肾脏手术中缺血的影响：大鼠组织学研究
Acta Cir Bras. 2006 Jul-Aug;21(4):242-6. doi: 10.1590/s0102-86502006000400010.
8
Kidney dysfunction in the postoperative period.
Br J Anaesth. 2005 Jul;95(1):20-32. doi: 10.1093/bja/aei018. Epub 2004 Nov 5.

High doses of ketamine to improve neuronal edema in subarachnoid hemorrhage: we should consider other undesirable organ targets.

作者信息

Honore Patrick M, Mugisha Aude, Kugener Luc, Redant Sebastien, Attou Rachid, Gallerani Andrea, De Bels David

机构信息

ICU Department, Centre Hospitalier Universitaire Brugmann-Brugmann University Hospital, Place Van Gehuchtenplein, 4, 1020, Brussels, Belgium.

出版信息

Crit Care. 2020 Jun 18;24(1):362. doi: 10.1186/s13054-020-03004-3.

DOI:10.1186/s13054-020-03004-3
PMID:32552903
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7304164/
Abstract
摘要