Ma Chun-Ya, Luo Yuan-Yuan, Yang Lu, Feng Yan-Nan, Sun Xiao-Lin, Zou Wen-Juan, Wang De-Qing, Yu Yang
Department of Blood Transfusion, Center for Clinical Transfusion Medicine, Chinese PLA General Hospital, Beijing 100853, China.
Department of Blood Transfusion, Center for Clinical Transfusion Medicine, Chinese PLA General Hospital, Beijing 100853, China,E-mail:
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2020 Jun;28(3):904-908. doi: 10.19746/j.cnki.issn.1009-2137.2020.03.031.
To evaluate the characteristics of autoimmune hemolytic anemia caused by salvianolate by antibody detection and clinical index monitoring.
Micro-column gel anti-human globulin method was used for irregular antibody screening and antibody identification. Salvianolate, sodium creatine phosphate and levocarnitine were used to sensitize red blood cells that were compatible with the patient's plasma, and the RBCs were used to test drug antibody in patient plasma respectively. The patient's clinical examination of hemolysis index and blood transfusion effect were analyed retrospectively.
The patients were positive for irregular antibody screening, and there were antoanti-Ce antibodies in serum. The erythrocytes sensitized with salvianolate in the patient's serum were positive, while those sensitized with sodium creatine phosphate and levocarnitine were negative.
Salvianolate causes drug-induced autoimmune hemolytic anemia in this patient.
通过抗体检测及临床指标监测，评估丹参多酚酸盐所致自身免疫性溶血性贫血的特点。
采用微柱凝胶抗人球蛋白法进行不规则抗体筛查及抗体鉴定。用丹参多酚酸盐、磷酸肌酸钠及左卡尼汀致敏与患者血浆相匹配的红细胞，分别用于检测患者血浆中的药物抗体。回顾性分析患者的溶血指标临床检查及输血效果。
患者不规则抗体筛查呈阳性，血清中有抗 - Ce抗体。患者血清中用丹参多酚酸盐致敏的红细胞呈阳性，而用磷酸肌酸钠和左卡尼汀致敏的红细胞呈阴性。
丹参多酚酸盐在该患者中引起药物性自身免疫性溶血性贫血。
