Lundgren P, Carr L A
Pharmacol Biochem Behav. 1978 Oct;9(4):559-61. doi: 10.1016/0091-3057(78)90059-x.
Mice were injected with anisomycin, an inhibitor of cerebral protein synthesis; d-amphetamine, strychnine, or caffeine was administered 30 min later. Fifteen min before sacrifice at 1 or 2 hr after injection of anisomycin, 3H-tyrosine was injected intravenously, and catecholamine synthesis rates were estimated by measurement of the specific activity of 3H-tyrosine and the accumulation of 3H-norepinephrine and 3H-dopamine. Anisomycin decreased synthesis rates of catecholamines, but this effect was not significantly affected by any of the CNS stimulants. These results suggest that the recently reported reversal of anisomycin-induced amnesia by these stimulants is not due to an attenuation of brain catecholamine synthesis inhibition.
给小鼠注射茴香霉素（一种脑蛋白合成抑制剂）；30分钟后给予d-苯丙胺、士的宁或咖啡因。在注射茴香霉素后1或2小时处死前15分钟，静脉注射3H-酪氨酸，并通过测量3H-酪氨酸的比活性以及3H-去甲肾上腺素和3H-多巴胺的积累来估计儿茶酚胺的合成速率。茴香霉素降低了儿茶酚胺的合成速率，但这种作用并未受到任何一种中枢神经系统兴奋剂的显著影响。这些结果表明，最近报道的这些兴奋剂对茴香霉素诱导的失忆症的逆转作用并非由于脑儿茶酚胺合成抑制作用的减弱。
