关于记忆的研究：蛋白质合成抑制剂也会抑制儿茶酚胺的合成。
Studies on memory: inhibitors of protein synthesis also inhibit catecholamine synthesis.
作者信息
Flexner L B, Goodman R H
出版信息
Proc Natl Acad Sci U S A. 1975 Nov;72(11):4660-3. doi: 10.1073/pnas.72.11.4660.
Abstract
The rates of accumulation of newly synthesized catecholamines and endogenous catecholamine levels in mice were determined after treatment with cycloheximide, acetoxycycloheximde, puromycin, and anisomycin. The rates of accumulation were found to be decreased by all antibiotics tested, weakening the assumption that their amnestic effects are due solely to inhibition of protein synthesis.
摘要
在用环己酰亚胺、乙酰氧基环己酰亚胺、嘌呤霉素和茴香霉素处理小鼠后，测定了新合成儿茶酚胺的积累速率和内源性儿茶酚胺水平。发现所有测试的抗生素都降低了积累速率，这削弱了它们的遗忘作用仅归因于蛋白质合成抑制的假设。
相似文献
1
Studies on memory: inhibitors of protein synthesis also inhibit catecholamine synthesis.关于记忆的研究：蛋白质合成抑制剂也会抑制儿茶酚胺的合成。
Proc Natl Acad Sci U S A. 1975 Nov;72(11):4660-3. doi: 10.1073/pnas.72.11.4660.
2
Effects of anisomycin and CNS stimulants on brain catecholamine synthesis.茴香霉素和中枢神经系统兴奋剂对脑儿茶酚胺合成的影响。
Pharmacol Biochem Behav. 1978 Oct;9(4):559-61. doi: 10.1016/0091-3057(78)90059-x.
3
A comparison of the effects of localized brain administration of catecholamine and protein synthesis inhibitors on memory processing.
Brain Res. 1980 Sep 15;197(1):153-65. doi: 10.1016/0006-8993(80)90441-2.
4
Protein synthesis and memory: a review.蛋白质合成与记忆：综述
Psychol Bull. 1984 Nov;96(3):518-59.
5
Anisomycin, acetoxycycloheximide, cycloheximide, and puromycin as inhibitors of rat brain acetylcholinesterase in vitro.茴香霉素、乙酰氧基环己酰亚胺、环己酰亚胺和嘌呤霉素作为大鼠脑乙酰胆碱酯酶体外抑制剂的研究
J Neurochem. 1976 Jun;26(6):1155-7. doi: 10.1111/j.1471-4159.1976.tb07000.x.
6
The effects of Cycloheximide and Anisomycin on monoamine synthesis in a brain synaptosome preparation.放线菌酮和茴香霉素对脑突触体制剂中单胺合成的影响。
J Neural Transm. 1982;54(1-2):41-50. doi: 10.1007/BF01249277.
7
Effects of amino acid alterations caused by protein synthesis inhibitors on brain monoamine formation.
Neuropharmacology. 1982 Sep;21(9):839-45. doi: 10.1016/0028-3908(82)90073-9.
8
Inhibition of acetylcholinesterase by anisomycin.
Life Sci. 1976 Jul 15;19(2):157-61. doi: 10.1016/0024-3205(76)90386-6.
9
Stimulatory effects of protein synthesis inhibitors on the spreading rate of 3T3 cells.蛋白质合成抑制剂对3T3细胞铺展速率的刺激作用。
Cell Biol Int Rep. 1989 Mar;13(3):231-5. doi: 10.1016/0309-1651(89)90145-8.
10
The effect of acetoxycycloheximide on rate of accumulation of cerebral catecholamines from circulating tyrosine as related to its effect on memory.乙酰氧基环己酰亚胺对脑儿茶酚胺从循环酪氨酸积累速率的影响及其与对记忆影响的关系。
Proc Natl Acad Sci U S A. 1975 Feb;72(2):479-82. doi: 10.1073/pnas.72.2.479.
引用本文的文献
1
Emotional Modulation of Learning and Memory: Pharmacological Implications.学习与记忆的情绪调节：药理学意义
Pharmacol Rev. 2017 Jul;69(3):236-255. doi: 10.1124/pr.116.013474.
2
Updating Procedures Can Reorganize the Neural Circuit Supporting a Fear Memory.更新程序可以重组支持恐惧记忆的神经回路。
Neuropsychopharmacology. 2017 Jul;42(8):1688-1697. doi: 10.1038/npp.2017.23. Epub 2017 Jan 31.
3
The amygdala is critical for trace, delay, and contextual fear conditioning.杏仁核对于痕迹、延迟和情境恐惧条件反射至关重要。
Learn Mem. 2015 Jan 15;22(2):92-100. doi: 10.1101/lm.034918.114. Print 2015 Feb.
4
Dopamine depletion attenuates some behavioral abnormalities in a hyperdopaminergic mouse model of bipolar disorder.多巴胺耗竭可减轻双相情感障碍的过度多巴胺能小鼠模型中的一些行为异常。
J Affect Disord. 2014 Feb;155:247-54. doi: 10.1016/j.jad.2013.08.041. Epub 2013 Nov 16.
5
Multiple components of eIF4F are required for protein synthesis-dependent hippocampal long-term potentiation.eIF4F 的多个成分是蛋白合成依赖性海马体长时程增强所必需的。
J Neurophysiol. 2013 Jan;109(1):68-76. doi: 10.1152/jn.00342.2012. Epub 2012 Oct 10.
6
On the dynamic nature of the engram: evidence for circuit-level reorganization of object memory traces following reactivation.关于记忆痕迹的动态本质：重激活后物体记忆痕迹的回路水平重新组织的证据。
J Neurosci. 2011 Nov 30;31(48):17719-28. doi: 10.1523/JNEUROSCI.2968-11.2011.
7
Memory consolidation in both trace and delay fear conditioning is disrupted by intra-amygdala infusion of the protein synthesis inhibitor anisomycin.在痕迹和延迟恐惧条件反射中，内侧杏仁核内注射蛋白合成抑制剂放线菌酮会破坏记忆巩固。
Learn Mem. 2011 Oct 25;18(11):728-32. doi: 10.1101/lm.023945.111. Print 2011 Nov.
8
Lidocaine attenuates anisomycin-induced amnesia and release of norepinephrine in the amygdala.利多卡因可减轻安非他命诱导的杏仁核去甲肾上腺素释放和记忆障碍。
Neurobiol Learn Mem. 2011 Sep;96(2):136-42. doi: 10.1016/j.nlm.2011.03.007. Epub 2011 Mar 29.
9
Intrahippocampal infusions of anisomycin produce amnesia: contribution of increased release of norepinephrine, dopamine, and acetylcholine.海马体内注射茴香霉素会导致失忆：去甲肾上腺素、多巴胺和乙酰胆碱释放增加的作用。
Learn Mem. 2009 Apr 29;16(5):308-14. doi: 10.1101/lm.1333409. Print 2009 May.
10
The role of protein synthesis in memory consolidation: progress amid decades of debate.蛋白质合成在记忆巩固中的作用：历经数十年争论后的进展。
Neurobiol Learn Mem. 2008 Mar;89(3):293-311. doi: 10.1016/j.nlm.2007.09.010. Epub 2007 Nov 28.
本文引用的文献
1
A study of the factors affecting the aluminum oxide-trihydroxyindole procedure for the analysis of catecholamines.一项关于影响用于儿茶酚胺分析的氧化铝 - 三羟基吲哚法的因素的研究。
J Pharmacol Exp Ther. 1962 Dec;138:360-75.
2
A fluorometric method for the estimation of tyrosine in plasma and tissues.一种用于估算血浆和组织中酪氨酸的荧光测定法。
J Lab Clin Med. 1957 Nov;50(5):733-6.
3
Comparative effects of cycloheximide and puromycin on cerebral protein synthesis and consolidation of memory in mice.放线菌酮和嘌呤霉素对小鼠大脑蛋白质合成及记忆巩固的比较作用
Brain Res. 1967 Feb;4(1):44-51. doi: 10.1016/0006-8993(67)90147-3.
4
Chemical studies on memory fixation in goldfish.金鱼记忆固定的化学研究。
Brain Res. 1966 Mar-Apr;1(3):303-9. doi: 10.1016/0006-8993(66)90095-3.
5
Selective release of newly synthesized norepinephrine from the cat spleen during sympathetic nerve stimulation.交感神经刺激期间猫脾脏中新合成去甲肾上腺素的选择性释放。
J Pharmacol Exp Ther. 1968 Jun;161(2):271-8.
6
Tryptophan transport in Neurospora crassa. II. Metabolic control.粗糙脉孢菌中的色氨酸转运。II. 代谢控制。
J Bacteriol. 1968 Mar;95(3):959-66. doi: 10.1128/jb.95.3.959-966.1968.
7
Inhibition of protein synthesis and simulation of permease turnover in yeast.酵母中蛋白质合成的抑制及通透酶周转的模拟
Biochem Biophys Res Commun. 1968 Feb 26;30(4):414-9. doi: 10.1016/0006-291x(68)90760-2.
8
Acquisition, storage, and recall of memory for brightness discrimination by rats following intracerebral infusion of acetoxycycloheximide.
J Comp Physiol Psychol. 1971 Jul;76(1):110-8. doi: 10.1037/h0031044.
9
Solubilization and partial purification of tyrosine hydroxylase from bovine adrenal medulla.牛肾上腺髓质酪氨酸羟化酶的增溶与部分纯化
J Biol Chem. 1971 Mar 10;246(5):1330-40.
10
Temporal characteristics of amnesia induced by protein synthesis inhibitor: determination by shock level.蛋白质合成抑制剂诱发失忆的时间特征：由休克水平决定
Nature. 1970 Nov 14;228(5272):677-8. doi: 10.1038/228677a0.
Zotero 插件