1Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom.
2Department of Medical Microbiology and Parasitology, School of Medical Sciences, Universiti Sains Malaysia, Kelantan, Malaysia.
Am J Trop Med Hyg. 2020 Aug;103(2):558-560. doi: 10.4269/ajtmh.20-0467. Epub 2020 Jun 16.
Rapid diagnostic tests (RDTs) play a critical role in malaria diagnosis and control. The emergence of parasites that can evade detection by RDTs threatens control and elimination efforts. These parasites lack or have altered genes encoding histidine-rich proteins (HRPs) 2 and 3, the antigens recognized by HRP2-based RDTs. Surveillance of such parasites is dependent on identifying false-negative RDT results among suspected malaria cases, a task made more challenging during the current pandemic because of the overlap of symptoms between malaria and COVID-19, particularly in areas of low malaria transmission. Here, we share our perspective on the emergence of parasites lacking HRP2 and HRP3, and the surveillance needed to identify them amid the COVID-19 pandemic.
快速诊断检测（RDT）在疟疾诊断和控制中发挥着关键作用。能够逃避 RDT 检测的寄生虫的出现，威胁着控制和消除工作。这些寄生虫缺乏或改变了编码富含组氨酸蛋白（HRP）2 和 3 的基因，而 HRP2 为基础的 RDT 正是针对这些抗原进行检测的。对这些寄生虫的监测依赖于识别疑似疟疾病例中 RDT 结果的假阴性，由于疟疾和 COVID-19 之间症状的重叠，特别是在疟疾传播率较低的地区，目前大流行期间这一任务更加具有挑战性。在这里，我们分享我们对缺乏 HRP2 和 HRP3 的寄生虫的出现的看法，以及在 COVID-19 大流行期间需要进行的监测，以识别这些寄生虫。
