Department of Neurology, Yeungnam University of College of Medicine, Daegu, Korea.
Department of Neurology, Severance Hospital, Yonsei University, College of Medicine, Seoul, Korea.
J Affect Disord. 2020 Jul 1;272:215-222. doi: 10.1016/j.jad.2020.03.102. Epub 2020 Apr 29.
A close association has been reported between depression and migraine. However, information concerning the impacts of migraine on the clinical presentation and prevalence of depression in a population-based study is currently limited.
Data from the Korean Headache-Sleep Study, a nationwide survey about headache and sleep for adults aged 19-69 years were used. Depression was defined when Patient Health Questionnaire-9 score ≥ 10.
Of 2,695 participants who included in this study, 116 (4.3%), 143 (5.3%), and 1130 (41.9%) had depression, migraine, and non-migraine headache, respectively. Migraine (24/116 [20.5%] vs. 119/2579 [4.7%], p < 0.001) and non-migraine headache (67/116 [58.1%] vs. 1063/2579 [41.3%], p < 0.001) was more prevalent in the group of participants with depression than among participants without depression. Among participants with depression, there was no statistically differences in total Patient Health Questionnaire-9 (PHQ-9) scores among migraine, non-migraine headache, and non-headache groups (median with interquartile range, 12.0 [10.2-18.0] vs. 13.0 [11.0-16.0] vs. 12.0 [10.0-15.2], p = 0.514). Among subcomponent scores of PHQ-9, all subcomponent scores did not significantly differ by headache status except feeling tired or having little energy scores (non-migraine headache 2.0 [2.0-3.0] vs. non-headache 2.0 [1.0-2.0], p = 0.010).
Diagnosis of depression based on PHQ-9 questionnaire and small sample size in subgroup analyses.
Participants with depression exhibit an increased risk of migraine and non-migraine headache compared with participants without depression. Among participants with depression, the severity of depression did not significantly differ on the basis of headache status.
已有报道称抑郁与偏头痛密切相关。然而，目前基于人群的研究中有关偏头痛对抑郁临床表现和患病率影响的信息有限。
本研究使用了韩国头痛-睡眠研究的数据，这是一项针对 19-69 岁成年人头痛和睡眠的全国性调查。当患者健康问卷-9 得分≥10 分时，定义为患有抑郁。
在纳入本研究的 2695 名参与者中，分别有 116 人（4.3%）、143 人（5.3%）和 1130 人（41.9%）患有抑郁、偏头痛和非偏头痛性头痛。与无抑郁的参与者相比，抑郁组中偏头痛（24/116 [20.5%] 比 2579 例中的 119 例 [4.7%] ，p<0.001）和非偏头痛性头痛（67/116 [58.1%] 比 2579 例中的 1063 例 [41.3%] ，p<0.001）更为普遍。在患有抑郁的参与者中，偏头痛、非偏头痛性头痛和无头痛组之间的总患者健康问卷-9（PHQ-9）评分无统计学差异（中位数 [四分位距]，12.0 [10.2-18.0] 比 13.0 [11.0-16.0] 比 12.0 [10.0-15.2] ，p=0.514）。在 PHQ-9 的子量表评分中，除疲倦或乏力评分外（非偏头痛性头痛 2.0 [2.0-3.0] 比无头痛 2.0 [1.0-2.0] ，p=0.010），其他各子量表评分在头痛状态上无显著差异。
基于 PHQ-9 问卷诊断抑郁和亚组分析中样本量小。
与无抑郁的参与者相比，患有抑郁的参与者发生偏头痛和非偏头痛性头痛的风险增加。在患有抑郁的参与者中，头痛状态与抑郁严重程度无显著相关性。
