Department of Psychology, Renmin University of China, 59# Zhongguancun Street, Haidian District, Beijing 100872, China.
Department of Psychology, Renmin University of China, 59# Zhongguancun Street, Haidian District, Beijing 100872, China.
J Affect Disord. 2020 Jul 1;272:283-288. doi: 10.1016/j.jad.2020.03.160. Epub 2020 Apr 29.
Work stress has been proved to be linked to depression, and both can decrease general trust. Likewise, OXTR gene is currently the gene that is most closely associated with trust. However, few empirical studies have explored the significant role of gene-environment interactions on general trust. In this study, we explored the mediating role of depression in the relationship between work stress and general trust, and the moderating role of the OXTR rs 53576 in the mediation model.
364 healthy Han Chinese faculties were recruited from one university in Beijing. Work stress, depression, and general trust were assessed using the House and Rizzo's Work Stress Scale, Self-Rating Depression Scale (SDS), and the General Trust Questionnaire, respectively. Blood samples were collected for OXTR rs53576 genotyping.
Depression mediated the relationship between work stress and general trust. In the mediation model, OXTR rs53576 could only moderated the direct path from work stress to general trust. For AA and GA individuals, depression completely mediated the relationship between work stress and general trust. For GG individuals, depression partly mediated the relationship between work stress and general trust.
This study used a cross-sectional design, only considered Han Chinese faculties, and the role of other genes should be explored.
Depression has a mediating effect between work stress and general trust. The general trust levels of GG genotype individuals are more prone to be affected by work stress than AA and GA individuals.
工作压力已被证明与抑郁有关，两者均会降低一般信任度。同样，OXTR 基因是目前与信任最密切相关的基因。然而，很少有实证研究探讨基因-环境相互作用对一般信任的重要作用。在这项研究中，我们探讨了抑郁在工作压力与一般信任之间的关系中的中介作用，以及 OXTR rs53576 在中介模型中的调节作用。
从北京一所大学招募了 364 名健康的汉族教职员工。使用 House 和 Rizzo 的工作压力量表、自评抑郁量表（SDS）和一般信任问卷分别评估工作压力、抑郁和一般信任。采集血样进行 OXTR rs53576 基因分型。
抑郁中介了工作压力与一般信任之间的关系。在中介模型中，OXTR rs53576 只能调节工作压力与一般信任之间的直接路径。对于 AA 和 GA 个体，抑郁完全中介了工作压力与一般信任之间的关系。对于 GG 个体，抑郁部分中介了工作压力与一般信任之间的关系。
本研究采用横断面设计，仅考虑汉族教职员工，应探索其他基因的作用。
抑郁在工作压力与一般信任之间具有中介作用。GG 基因型个体的一般信任水平比 AA 和 GA 个体更容易受到工作压力的影响。
