早期杜氏肌营养不良症患儿的肺部和上肢功能与健康同龄儿比较。
Pulmonary and upper limbs function in children with early stage Duchenne muscular dystrophy compared to their healthy peers.
机构信息
Faculty of Physical Therapy and Rehabilitation, Hacettepe University, Ankara, Turkey.
Faculty of Physical Therapy and Rehabilitation, Hacettepe University, Ankara, Turkey.
出版信息
Braz J Phys Ther. 2021 May-Jun;25(3):251-255. doi: 10.1016/j.bjpt.2020.05.012. Epub 2020 Jun 5.
BACKGROUND
Pulmonary and upper limbs function of children with Duchenne muscular dystrophy (DMD) are known to deteriorate throughout the disease process. However, there is a lack of information on the extent of impairments in the early stages of DMD when compared to healthy peers.
OBJECTIVE
To investigate to what extent pulmonary and upper limbs function of children with early stage DMD are impaired.
METHODS
Sixty-one children participated in the study: 31 with Grade 1 DMD (study group) according to the Brooke Upper and Lower Extremity Functional Classification Systems, and 30 age matched healthy peers (control group). Pulmonary function was determined with pulmonary function tests. The Performance of Upper Limb test was used to evaluate the upper limbs function.
RESULTS
Study and control groups were homogenous in terms of physical characteristics (p>0.05). Pulmonary and upper limbs function of children with DMD were about 85% and 93% of healthy peers, respectively.
CONCLUSION
This study provides evidence for deterioration of pulmonary and upper limbs function in children with early stage DMD. Better knowledge of deterioration rate over time may help therapists to better plan and update their plan of care.
背景
已知杜氏肌营养不良症（DMD）患儿的肺部和上肢功能会随着疾病的发展而逐渐恶化。然而，与健康同龄人相比，在 DMD 的早期阶段，其受损程度的相关信息却较为缺乏。
目的
探讨早期 DMD 患儿的肺部和上肢功能受损的程度。
方法
本研究纳入了 61 名儿童：31 名根据布鲁克上下肢功能分类系统评定为 1 级 DMD（研究组），30 名年龄匹配的健康同龄人（对照组）。通过肺功能检查评估肺部功能，使用上肢功能测试评估上肢功能。
结果
研究组和对照组在身体特征方面具有同质性（p＞0.05）。DMD 患儿的肺部和上肢功能分别约为健康同龄人的 85%和 93%。
结论
本研究为早期 DMD 患儿肺部和上肢功能的恶化提供了证据。更好地了解随时间的恶化率可能有助于治疗师更好地计划和更新他们的护理计划。
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