Department of Developmental and Regenerative Neurobiology, Institute of Brain Science, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, Aichi, 467-8601, Japan; Department of Pharmacy, Noakhali Science and Technology University, Noakhali 3814, Bangladesh.
Department of Developmental and Regenerative Neurobiology, Institute of Brain Science, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, Aichi, 467-8601, Japan; Division of Neural Development and Regeneration, National Institute for Physiological Sciences, National Institutes of Natural Sciences, 5-1 Higashiyama, Myodaiji, Okazaki, Aichi, 444-8787, Japan.
Neurosci Res. 2021 Jun;167:64-69. doi: 10.1016/j.neures.2020.06.001. Epub 2020 Jun 15.
The ventricular-subventricular zone (V-SVZ) is located in the walls of the lateral ventricles and produces new neurons in the postnatal brain of mammals, including humans. Immature new neurons called "neuroblasts" generated by neural stem cells in the V-SVZ migrate toward their final destinations and contribute to brain development and plasticity. In this review, we describe recent progress in understanding the similarities and dissimilarities in postnatal neurogenesis and neuronal migration between rodents and primates. In rodents, most new V-SVZ-derived neurons migrate along the rostral migratory stream towards the olfactory bulb, where they differentiate into interneurons. In contrast, in humans, the extensive migration of new neurons towards the neocortex continues for several months after birth and might be involved in the development of the expanded neocortex. The mode of migration and the fate of neuroblasts seem to change depending on their environment, destination, and roles in the brain. A better understanding of these similarities and differences between rodents and primates will help translate important findings from animal models and may contribute to the development of clinical strategies for brain repair.
脑室-脑室外区（V-SVZ）位于侧脑室壁，在哺乳动物（包括人类）的出生后大脑中产生新的神经元。V-SVZ 中的神经干细胞产生的未成熟新神经元称为“神经母细胞”，它们向最终目的地迁移，并有助于大脑发育和可塑性。在这篇综述中，我们描述了在理解啮齿动物和灵长类动物之间出生后神经发生和神经元迁移的相似性和差异性方面的最新进展。在啮齿动物中，大多数新的 V-SVZ 衍生神经元沿着向嗅球的前迁移流迁移，在那里它们分化为中间神经元。相比之下，在人类中，新神经元向大脑皮层的广泛迁移在出生后持续几个月，可能参与了扩展的大脑皮层的发育。神经母细胞的迁移模式和命运似乎取决于其环境、目的地和在大脑中的作用而发生变化。更好地理解啮齿动物和灵长类动物之间的这些相似性和差异性将有助于将动物模型中的重要发现转化，并可能有助于开发大脑修复的临床策略。
