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抑郁症对全髋关节置换术后早期翻修、麻醉药物使用及预后影响的可改变性:心理治疗的作用

Modifiability of Depression's Impact on Early Revision, Narcotic Usage, and Outcomes After Total Hip Arthroplasty: The Impact of Psychotherapy.

作者信息

Schwartz Andrew M, Wilson Jacob M, Farley Kevin X, Roberson James R, Guild George N, Bradbury Thomas L

机构信息

Department of Orthopaedic Surgery, Emory Orthopaedics & Spine Center, Atlanta, GA.

出版信息

J Arthroplasty. 2020 Oct;35(10):2904-2910. doi: 10.1016/j.arth.2020.05.021. Epub 2020 May 16.

Abstract

BACKGROUND

Depression is known to negatively influence functional recovery, patient satisfaction, narcotic requirements, implant survivorship, and perioperative resource utilization after total hip arthroplasty (THA). The degree to which this effect is modifiable is largely unknown, with mixed results on preoperative pharmacological intervention, and concomitant concerns over side effects. We aim to investigate the influence of psychotherapy before THA on surgical outcomes, medical complications, and resource utilization.

METHODS

A retrospective chart review of Truven MarketScan Databases was performed to generate 3 cohorts: patients without depression, patients with depression who did not receive preoperative psychotherapy, and patients with depression who received psychotherapy before surgery. Outcomes of interest were resource utilization, surgical and medical complications, narcotic requirements, and 1-year and 3-year revision rates.

RESULTS

On multivariate analysis, depressed patients who did not receive psychotherapy were more likely to be discharged to inpatient rehabilitation facility (odds ratio [OR] 1.28, 95% confidence interval [CI] 1.10-1.48, P < .001) and require 2 or more postoperative narcotic prescriptions (OR 1.20, 95% CI 1.06-1.37, P = .004) than depressed patients who received psychotherapy. Patients who did not receive psychotherapy were more likely to have continued narcotic requirements within 1 year after surgery (OR 1.23, 95% CI 1.08-1.39, P < .001) and undergo revision at 1 year (OR 1.74, 95% CI 1.17-2.58, P = .006) and 3 years (OR 1.92, 95% CI 1.10-3.34, P = .021) than depressed patients who received psychotherapy.

CONCLUSION

The negative influence of depression on narcotic requirements, resource utilization, and implant survivorship after THA appears to be modifiable with preoperative psychotherapy.

摘要

背景

众所周知,抑郁症会对全髋关节置换术(THA)后的功能恢复、患者满意度、麻醉药物需求、植入物存活率以及围手术期资源利用产生负面影响。这种影响在多大程度上可以改变在很大程度上尚不清楚,术前药物干预的结果不一,同时还存在对副作用的担忧。我们旨在研究THA术前心理治疗对外科手术结果、医疗并发症和资源利用的影响。

方法

对Truven MarketScan数据库进行回顾性图表审查,以生成3个队列:无抑郁症患者、未接受术前心理治疗的抑郁症患者以及术前接受心理治疗的抑郁症患者。感兴趣的结果是资源利用、手术和医疗并发症、麻醉药物需求以及1年和3年翻修率。

结果

多变量分析显示,未接受心理治疗的抑郁症患者比接受心理治疗的抑郁症患者更有可能被转至住院康复机构(比值比[OR]1.28,95%置信区间[CI]1.10 - 1.48,P <.001),并且需要2张或更多术后麻醉药物处方(OR 1.20,95% CI 1.06 - 1.37,P =.004)。未接受心理治疗的患者在术后1年内更有可能持续需要麻醉药物(OR 1.23,95% CI 1.08 - 1.39,P <.001),并且在1年(OR 1.74,95% CI 1.17 - 2.58,P =.006)和3年(OR 1.92,95% CI 1.10 - 3.34,P =.021)时比接受心理治疗的抑郁症患者更有可能进行翻修。

结论

抑郁症对THA后麻醉药物需求、资源利用和植入物存活率的负面影响似乎可以通过术前心理治疗得到改善。

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